EX-99 2 ex_1sc13g-adams.txt EXHIBIT 1 CUSIP NO. 00635P107 Schedule 13G Page 20 of 24 EXHIBIT 1 --------- JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained herein, but shall not be responsible for the completeness and accuracy of the information concerning the other entities or persons, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate. Dated as of February 14, 2006 PERSEUS-SOROS BIOPHARMACEUTICAL FUND, LP By: Perseus-Soros Partners, LLC General Partner By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel CUSIP NO. 00635P107 Schedule 13G Page 21 of 24 PERSEUS-SOROS PARTNERS, LLC By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel PERSEUS BIOTECH FUND PARTNERS, LLC By: Perseuspur, LLC Member By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer SFM PARTICIPATION, L.P. By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel CUSIP NO. 00635P107 Schedule 13G Page 22 of 24 SFM AH LLC By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel PERSEUSPUR, LLC By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer MR. FRANK H. PEARL By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Attorney-in-Fact MR. GEORGE SOROS By: /s/ Jodye M. Anzalotta ---------------------------------------- Name: Jodye M. Anzalotta Title: Attorney-in-Fact SOROS FUND MANAGEMENT LLC By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel