Collaboration, Licensing and Other Arrangements - Schedule of Effect of Modification on Transaction Price (Detail) - Collaboration and License Agreement - United Therapeutics Corporation $ in Millions	Oct. 31, 2021 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Anticipated Cash Flow	$ 463.5	[1]
R&D Services and License | Over Time
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Progress Measure	Ratably	[2]
Recognition Period	Aug 2021 - Oct 2021	[2],[3]
Next-Gen R&D Services | Over Time
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Anticipated Revenue Allocation	$ 4.8	[4],[5]
Progress Measure	Input	[4]
Recognition Period	% of completion of costs	[4],[6]
Manufacturing Services | Point In Time
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Anticipated Revenue Allocation	$ 458.7	[5],[7]
Recognition Period	Transfer of control	[7],[8]

[1] The total anticipated cash flow includes a transaction price of $64.3 million for the contractual obligations under the CSA for the Manufacturing Services and the Next-Gen R&D Services performance obligations and $399.2 million for future supply of Tyvaso DPI over the remaining term of the CSA.

[2] The license for the Company’s IP was considered to be interdependent with the development activities to support approval of Tyvaso DPI. A sales-based royalty is promised in exchange for the IP license; therefore, the royalties associated with the license are excluded from the determination of the transaction price and the Company will recognize revenue as the sale of Tyvaso DPI to a patient occurs.

[3] Represents the period when the revenue for the R&D Services performance obligation was recognized.

[4] The standalone selling price (“SSP”) for the Next-Gen R&D Services performance obligation was based on industry ratios as well as the Company’s historical R&D projects. The transaction price for the Next-Gen R&D Services was based on fixed consideration which was allocated between performance obligations as discussed in note (2) above.

[5] Allocation is based on management’s assessment of the stand-alone selling price of each performance obligation.

[6] The Next-Gen R&D Services performance obligation will be satisfied over time using the input method based on the costs incurred to date as a percentage of the total estimated costs to fulfill the contract. Incurred cost represents work performed, which corresponds with, and thereby best depicts, the transfer of control to the customer.

[7] Pre-production activities under the CSA, such as facility expansion services and certain other administrative services, were considered bundled services that are part of the Company’s Manufacturing Services performance obligation, given the nature of the Company’s contractual responsibilities and ASC 606 requirements.

[8] The Manufacturing Services performance obligation will be recognized as control of manufactured products is transferred to UT. The modification did not result in a cumulative catch-up adjustment as a result of the revenue being deferred for the performance obligations that were affected by the modification. The allocation of transaction price includes a material right related to manufacturing services in the amount of $144.5 million. The total anticipated cash flow is based on the Company’s estimated production and the ultimate cash flows may vary as manufacturing purchase orders are received.