Income Taxes - Additional Information (Detail) - USD ($)	1 Months Ended	12 Months Ended
	Aug. 31, 2004	Dec. 31, 2021	Dec. 31, 2020
Income Taxes [Line Items]
Valuation allowance of deferred tax asset		$ 695,094,000	$ 675,463,000
Change in the valuation allowance		19,631,000	4,846,000
Federal operating loss carryforwards		2,200,000,000
State operating loss carryforwards		1,300,000,000
Federal operation loss carryforwards, not subject to expiration		$ 452,700,000
Operating loss carryforwards, limitations on use		Pursuant to IRC Sections 382 and 383, annual use of the Company’s federal and California net operating loss and research and development credit carryforwards may be limited in the event a cumulative change in ownership of more than 50% occurs within a three-year period.
Net operating loss carryforwards	$ 216,000,000.0
Net operating loss and credit carryforwards, annual use limitation	$ 13,000,000.0
Research and development credits begin to expire		2021
Research and development credits		$ 78,804,000	79,455,000
Research and development credits expire		1,200,000
Unrecognized income tax interest and penalties		0	0
Federal
Income Taxes [Line Items]
Research and development credits not expire		$ 54,200,000
Research and development credits begin to expire		2024
State
Income Taxes [Line Items]
Research and development credits not expire		$ 24,600,000
New Jersey
Income Taxes [Line Items]
Research and development credits begin to expire		2021
Connecticut
Income Taxes [Line Items]
Research and development credits not expire			19,800,000
Research and development credits			$ 100,000
California
Income Taxes [Line Items]
Research and development credits not expire		$ 2,000,000.0
Research and development credits		$ 2,200,000