Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Net operating loss carryforwards	$ 542,800	$ 533,448
Research and development credits	78,804	79,455
Milestone Rights	1,440	1,547
Accrued expenses	2,591	1,436
Loss on purchase commitment	24,845	23,864
Non-qualified stock option expense	5,684	3,766
Capitalized patent costs	7,518	5,273
Other	2,568	2,093
Lease liability	588	559
Interest expense limitation	5,696	2,460
Depreciation	22,983	20,735
Deferred Product Revenue & Costs	404	1,569
Total net deferred tax assets	695,921	676,205
Valuation allowance	(695,094)	(675,463)
Net deferred tax assets	827	742
Deferred tax liabilities:
Right of use asset	(555)	(510)
Other prepaids	(272)	(232)
Total deferred tax liabilities	$ (827)	$ (742)