Fair Value of Financial Instruments - Additional Information (Detail) - USD ($)	Dec. 31, 2021	Nov. 30, 2021	Dec. 31, 2020
Fair Value Of Financial Instruments [Line Items]
Cash and cash equivalents	$ 124,184,000		$ 67,005,000
Restricted cash			158,000
Short-term investments	79,932,000
Long-term investments	56,619,000
Financing liability, long term	93,525,000	$ 93,500,000
Financing liability, short term	6,977,000	$ 7,000,000.0
Convertible Promissory Note | Thirona Bio, Inc.
Fair Value Of Financial Instruments [Line Items]
Investment securities	3,000,000.0
Held-to-Maturity Investments
Fair Value Of Financial Instruments [Line Items]
Short-term investments	79,900,000
Long-term investments	56,600,000
Investments			0
Money Market Funds
Fair Value Of Financial Instruments [Line Items]
Cash and cash equivalents	124,200,000		67,000,000.0
Restricted cash	$ 0		$ 200,000