Description of Business and Significant Accounting Policies - Additional Information (Detail)				1 Months Ended		3 Months Ended		6 Months Ended
		Apr. 22, 2021 USD ($)	Apr. 10, 2020 USD ($)	Jun. 30, 2021 USD ($)	Mar. 31, 2021 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2020 USD ($)	Jun. 30, 2021 USD ($) Segment Contract	Jun. 30, 2020 USD ($)	Dec. 31, 2020 USD ($)	Aug. 31, 2019 USD ($)	Jul. 01, 2013 USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Accumulated deficit				$ (3,097,582,000)		$ (3,097,582,000)		$ (3,097,582,000)		$ (3,049,143,000)
Principal amount				293,300,000		293,300,000		293,300,000
Cash and cash equivalents				62,522,000		62,522,000	$ 63,222,000	62,522,000	$ 63,222,000	67,005,000
Short-term investments				99,970,000		99,970,000		99,970,000
Long-term investments				38,950,000		38,950,000		$ 38,950,000
Debt issuance amount					$ 230,000,000.0
Debt issuance percentage					2.50%
Number of operating segment | Segment								1
Proceeds from loans									4,873,000
Accretion or amortization						100,000	$ 0	$ 100,000	0
Allowance for credit losses on held-to-maturity securities				$ 0		$ 0		$ 0
ASU 2020-06
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Change in accounting principle accounting standards update adopted				true		true		true
Change in accounting principle accounting standards update adoption date				Jan. 01, 2021		Jan. 01, 2021		Jan. 01, 2021
Change in accounting principle accounting standards update immaterial effect				true		true		true
Change in accounting principle accounting standards update early adoption				true		true		true
Commitment Asset | Other Expense
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Asset impairment									$ 1,900,000
Paycheck Protection Program Loan, CARES Act
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Principal amount	[1]			$ 4,900,000		$ 4,900,000		$ 4,900,000		4,900,000
Proceeds from loans			$ 4,900,000
Convertible Promissory Note | Thirona Bio, Inc.
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Investment securities				3,000.0		$ 3,000.0		$ 3,000.0
Proceeds from investment securities				$ 3,000.0
Maturity date				2022-12
Interest rate				6.00%		6.00%		6.00%
Insulin
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Loss on purchase commitments				$ 88,700,000		$ 88,700,000		$ 88,700,000		95,300,000
Loss on purchase commitments, number of new contracts recognized | Contract								0
Maximum | AFREZZA product sales
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Sales return right following product expiration in months								12 months
Minimum | AFREZZA product sales
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Sales return right following product expiration in months								6 months
MidCap Credit Facility
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Principal amount	[2]			40,000,000.0		40,000,000.0		$ 40,000,000.0		50,000,000.0
Principal amount											$ 110,000,000.0
Amount outstanding				40,000,000.0		40,000,000.0		40,000,000.0		$ 50,000,000.0
Principal prepayment against outstanding term loans		$ 10,000,000.0
Commitment asset											1,500,000
Other asset											$ 400,000
Milestone Rights Liability | Deerfield
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Contingent liability remain payable				$ 65,000,000.0		$ 65,000,000.0		$ 65,000,000.0
Milestone Rights Liability | Maximum | Deerfield
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Contingent liability for milestone payments												$ 90,000,000.0

[1] In July 2021, the Company received full forgiveness from the SBA for the $4.9 million principal balance of the PPP loan.

[2] In April 2021, the Company prepaid $10.0 million principal balance and amended the MidCap credit facility. The interest rate prior to the amendment was one-month LIBOR (2% floor) plus 6.75% and the maturity date was in August 2024.