Description of Business and Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2019

Accounting Policies [Abstract]

Schedule of Potentially Dilutive Common Stock Equivalent Securities

The computation of basic and diluted net loss per share for the nine months ended September 30, 2019 and 2018 excludes the common stock equivalents of the following potentially dilutive securities because their inclusion would be anti-dilutive while the Company is in a net loss position:

	Nine months ended September 30,
	2019		2018
Vesting of restricted stock units		1,122,283		1,169,340
Employee stock purchase plan		147,675		97,598
Exercise of common stock options		15,361,337		11,431,526
Conversion of Senior Convertible Notes into common stock		1,666,667		3,629,627
Conversion of Promissory Notes into common stock		14,000,000		21,909,541
Exercise of common stock warrants		31,856		31,856
Exercise of warrants associated with Midcap Credit Facility		1,171,614	—
Exercise of warrants associated with public offering		23,333,333		—
Exercise of warrants associated with direct placement	—			14,000,000
Total shares		56,834,765		52,269,488