Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenues:
Total revenues	$ 27,859	$ 11,745	$ 174,758
Expenses:
Cost of goods sold	19,402	17,228	17,121
Research and development	8,737	14,118	14,917
Selling, general and administrative	79,716	74,959	46,928
Property and equipment impairment		203	1,259
(Gain) loss on foreign currency translation	(4,468)	13,641	(3,433)
Gain on purchase commitments	(10)	(215)	(2,265)
Total expenses	104,454	119,934	107,498
(Loss) income from operations	(76,595)	(108,189)	67,260
Other (expense) income:
Change in fair value of warrant liability		5,488	5,369
Interest income	501	293	85
Interest expense on notes	(5,116)	(9,494)	(15,576)
Interest expense on note payable to related party	(4,323)	(3,782)	(2,901)
(Loss) gain on extinguishment of debt	(765)	(1,611)	72,024
Other income (expense)	(437)	13	(597)
Total other (expense) income	(10,140)	(9,093)	58,404
(Loss) income before income tax expense	(86,735)	(117,282)	125,664
Provision for income taxes	240	51
Net (loss) income	$ (86,975)	$ (117,333)	$ 125,664
Net (loss) income per share - basic	$ (0.60)	$ (1.13)	$ 1.37
Net (loss) income per share - diluted	$ (0.60)	$ (1.13)	$ 1.36
Shares used to compute basic net (loss) income per share	144,136	104,245	92,053
Shares used to compute diluted net (loss) income per share	144,136	104,245	92,085
Commercial product sales
Revenues:
Total revenues	$ 17,276	$ 9,192	$ 1,895
Collaborations and services
Revenues:
Total revenues	10,583	250	171,965
Expenses:
Cost of revenue	$ 1,077		32,971
Revenue - other
Revenues:
Total revenues		$ 2,303	$ 898