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Collaboration Arrangements - Additional Information (Detail) - USD ($)
1 Months Ended 9 Months Ended
Dec. 30, 2016
May 31, 2018
Jan. 31, 2017
Sep. 30, 2018
Oct. 16, 2018
Dec. 31, 2016
Sanofi-Aventis Deutschland GmbH | Put Option            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Payment for insulin put option     $ 30,600,000      
Collaboration and License Agreement | United Therapeutics Corporation            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Revenue recognized during the period       $ 0    
Collaboration and License Agreement | United Therapeutics Corporation | Subsequent Event            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Upfront payment received         $ 45,000,000  
Collaboration and License Agreement | United Therapeutics Corporation | Maximum            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Potential milestone payments to be receive       50,000,000    
Additional option exercise and development milestone payments to be receive       $ 40,000,000    
Collaboration and License Agreement | Receptor            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Deferred revenue - nonrefundable license fee           $ 1,000,000
Deferred revenue recognition period       4 years    
Nonrefundable option exercise and license fee $ 1,000,000          
Deferred payments from collaboration       $ 600,000    
Deferred payments from collaboration, current       300,000    
Distribution Agreement | Foreign Country | India Tax Authority            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Income Taxes Paid       $ 200,000    
Distribution Agreement | Cipla Ltd            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Marketing and distribution agreement date   2018-05        
Deferred revenue - nonrefundable license fee   $ 2,200,000        
Deferred revenue recognition period       15 years    
Research Agreement | United Therapeutics Corporation            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Revenue recognized during the period       $ 0    
Upfront payment received       10,000,000    
Research Agreement | United Therapeutics Corporation | Maximum            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Additional milestone payments to be received       $ 30,000,000