Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Total revenues	$ 4,469	$ 2,043	$ 11,827	$ 7,215
Expenses:
Cost of goods sold	5,303	4,575	14,406	12,210
Research and development	2,043	4,361	7,653	10,611
Selling, general and administrative	19,394	17,725	61,740	51,681
Property and equipment impairment		92		203
(Gain) Loss on foreign currency translation	(728)	3,684	(3,107)	12,077
Gain on purchase commitments		(215)		(215)
Total expenses	26,012	30,222	80,692	86,567
Loss from operations	(21,543)	(28,179)	(68,865)	(79,352)
Other (expense) income:
Change in fair value of warrant liability		(1,289)		5,488
Interest income	144	65	305	178
Interest expense on notes	(993)	(2,310)	(4,496)	(7,438)
Interest expense on note payable to related party	(1,074)	(1,173)	(3,234)	(2,608)
Loss on extinguishment of debt	(712)		(765)	(830)
Other income	10		71	13
Total other expense	(2,625)	(4,707)	(8,119)	(5,197)
Loss before provision for income taxes	(24,168)	(32,886)	(76,984)	(84,549)
Income tax expense			(240)
Net loss	$ (24,168)	$ (32,886)	$ (77,224)	$ (84,549)
Net loss per share - basic and diluted	$ (0.16)	$ (0.31)	$ (0.56)	$ (0.84)
Shares used to compute basic and diluted net loss per share	153,597	104,703	138,307	100,136
Net revenue - commercial product sales
Revenues:
Total revenues	$ 4,387	$ 1,981	$ 11,542	$ 4,726
Net revenue - collaborations
Revenues:
Total revenues	$ 82	$ 62	232	187
Revenue - other
Revenues:
Total revenues			$ 53	$ 2,302