Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 10,446	$ 43,946
Restricted cash	527	4,409
Accounts receivable, net	2,752	2,789
Inventory	2,785	2,657
Deferred costs from commercial product sales		405
Prepaid expenses and other current assets	3,015	3,010
Total current assets	19,525	57,216
Property and equipment, net	25,632	26,922
Other assets	199	437
Total assets	45,356	84,575
Current liabilities:
Accounts payable	5,815	6,984
Accrued expenses and other current liabilities	13,434	12,449
Facility financing obligation	14,202	52,745
Deferred revenue, net		3,038
Deferred payments from collaboration - current	10,095	250
Recognized loss on purchase commitments - current	16,081	12,131
Total current liabilities	59,627	87,597
Note payable to related party	72,143	79,666
Accrued interest - note payable to related party	5,692	2,347
Senior convertible notes	19,133	24,411
Recognized loss on purchase commitments - long term	84,362	97,585
Deferred payments from collaboration - long term	2,638	500
Milestone rights liability	7,202	7,201
Total liabilities	250,797	299,307
Commitments and contingencies (Note 12)
Stockholders' deficit:
Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at September 30, 2018 and December 31, 2017
Common stock, $0.01 par value - 280,000,000 shares authorized, 159,497,573 and 119,053,414 shares issued and outstanding at September 30, 2018 and December 31, 2017, respectively	1,594	1,192
Additional paid-in capital	2,723,232	2,638,992
Accumulated other comprehensive loss	(18)	(18)
Accumulated deficit	(2,930,249)	(2,854,898)
Total stockholders' deficit	(205,441)	(214,732)
Total liabilities and stockholders' deficit	$ 45,356	$ 84,575