Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Total revenues	$ 3,893	$ 2,163	$ 7,358	$ 5,172
Expenses:
Cost of goods sold	5,095	5,086	9,103	7,635
Research and development	2,967	3,123	5,611	6,251
Selling, general and administrative	21,731	18,566	42,349	33,956
Property and equipment impairment		111		111
(Gain) Loss on foreign currency translation	(5,363)	6,848	(2,379)	8,392
Total expenses	24,430	33,734	54,684	56,345
Loss from operations	(20,537)	(31,571)	(47,326)	(51,173)
Other (expense) income:
Change in fair value of warrant liability		147		6,776
Interest income	55	58	161	114
Interest expense on notes	(1,709)	(2,422)	(3,503)	(5,128)
Interest expense on note payable to related party	(1,046)	(721)	(2,160)	(1,435)
Gain (Loss) on extinguishment of debt	772	(830)	(53)	(830)
Other income	30		61	13
Total other (expense)	(1,898)	(3,768)	(5,494)	(490)
Loss before provision for income taxes	(22,435)	(35,339)	(52,820)	(51,663)
Income tax expense	(240)		(240)
Net loss	$ (22,675)	$ (35,339)	$ (53,060)	$ (51,663)
Net loss per share - basic and diluted	$ (0.16)	$ (0.35)	$ (0.41)	$ (0.53)
Shares used to compute basic and diluted net loss per share	140,054	99,864	130,535	97,816
Net revenue - commercial product sales
Revenues:
Total revenues	$ 3,753	$ 1,548	$ 7,155	$ 2,745
Net revenue - collaboration
Revenues:
Total revenues	87	63	150	125
Revenue - other
Revenues:
Total revenues	$ 53	$ 552	$ 53	$ 2,302