Description of Business and Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2018

Summary Of Significant Accounting Policies [Line Items]

Schedule of Potentially Dilutive Common Stock Equivalent Securities

The computation of basic and diluted net loss per share for the six months ended June 30, 2018 and 2017 excludes the common stock equivalents of the following potentially dilutive securities because their inclusion would be anti-dilutive:

	June 30, 2018
	2018		2017
Vesting of restricted stock units		1,219,419		1,193,100
Employee stock purchase plan		248,067		—
Exercise of common stock options		11,368,356		7,972,175
Conversion of convertible notes into common stock		14,154,500		814,561
Conversion of convertible related party notes into common    stock		21,909,541		—
Exercise of common stock warrants		31,856		9,740,597
Exercise of warrants associated with direct placement		14,000,000		—
		62,931,739		19,720,433

Accounting Standards Update 2014-09

Summary Of Significant Accounting Policies [Line Items]

Schedule of Cumulative Effect of Changes to Condensed Consolidated Balance Sheet for Adoption of New Revenue Guidance

The cumulative effect of the changes made to the condensed consolidated January 1, 2018 balance sheet for the adoption of the new revenue guidance were as follows (in thousands):

	Balance at December 31, 2017			Adjustments due to new revenue guidance				Balance at January 1, 2018
Assets
Accounts receivable, net	$	2,789		$	(111	)	(1)	$	2,678
Deferred costs from commercial product    sales		405			(405	)	(2)		—
Liabilities
Accrued expenses and other current    liabilities	$	12,449		$	649		(3)	$	13,098
Deferred revenue, net		3,038			(3,038	)	(4)		—
Equity
Accumulated deficit	$	(2,854,898	)	$	1,873		(5)	$	(2,853,025	)

(1) To establish a reserve for product returns

(2) To eliminate deferred costs from commercial product sales previously required by the sell-through method

(3) To record additional accrual for estimated voucher payments related to inventory remaining in the distribution channel at January 1, 2018

(4) To eliminate deferred revenue previously required by the sell-through method

(5) To record the net impact of (1)-(4) in opening accumulated deficit

Schedule of Adoption of New Revenue Guidance Impact on Financial Statements

In accordance with the new revenue guidance, the disclosure of the impact of adoption on the condensed consolidated balance sheet and the condensed consolidated statement of operations and cash flows was as follows (in thousands):

	For the six months ended June 30, 2018
	As Reported			Adjustments			Balances without adoption of Topic 606
Cash Flows from Operating Activities
Net loss	$	(53,060	)	$	202		$	(52,858	)
Change in:
Accounts receivable, net		(170	)		(188	)		(358	)
Deferred costs from commercial product    sales		—			(1	)		(1	)
Accrued expenses and other current    liabilities		818			170			988
Deferred revenue, net		—			(348	)		(348	)
Cash (used in) provided by operating    activities		(48,800	)		(165	)		(48,965	)