Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 26,178	$ 43,946
Restricted cash	527	4,409
Accounts receivable, net	2,848	2,789
Inventory	3,676	2,657
Deferred costs from commercial product sales		405
Prepaid expenses and other current assets	2,570	3,010
Total current assets	35,799	57,216
Property and equipment, net	26,036	26,922
Other assets	320	437
Total assets	62,155	84,575
Current liabilities:
Accounts payable	9,237	6,984
Accrued expenses and other current liabilities	14,075	12,449
Facility financing obligation	38,002	52,745
Deferred revenue, net		3,038
Deferred payments from collaboration - current	396	250
Recognized loss on purchase commitments - current	13,191	12,131
Total current liabilities	74,901	87,597
Note payable to related party	72,196	79,666
Accrued interest - note payable to related party	4,566	2,347
Senior convertible notes	19,161	24,411
Recognized loss on purchase commitments - long term	88,346	97,585
Deferred payments from collaboration - long term	2,403	500
Milestone rights liability	7,201	7,201
Total liabilities	268,774	299,307
Commitments and contingencies (Note 12)
Stockholders' deficit:
Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at June 30, 2018 and December 31, 2017
Common stock, $0.01 par value - 280,000,000 shares authorized, 145,619,293 and 119,053,414 shares issued and outstanding at June 30, 2018 and December 31, 2017, respectively	1,456	1,192
Additional paid-in capital	2,698,028	2,638,992
Accumulated other comprehensive loss	(18)	(18)
Accumulated deficit	(2,906,085)	(2,854,898)
Total stockholders' deficit	(206,619)	(214,732)
Total liabilities and stockholders' deficit	$ 62,155	$ 84,575