Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 26,706	$ 43,946
Restricted cash	527	4,409
Accounts receivable, net	1,550	2,789
Inventory	3,891	2,657
Deferred costs from commercial product sales		405
Prepaid expenses and other current assets	2,354	3,010
Total current assets	35,028	57,216
Property and equipment, net	26,481	26,922
Other assets	368	437
Total assets	61,877	84,575
Current liabilities:
Accounts payable	4,976	6,984
Accrued expenses and other current liabilities	15,930	12,449
Facility financing obligation	43,654	52,745
Deferred revenue, net		3,038
Deferred payments from collaboration - current	250	250
Recognized loss on purchase commitments - current	15,859	12,131
Total current liabilities	80,669	87,597
Note payable to related party	72,247	79,666
Accrued interest - note payable to related party	3,469	2,347
Senior convertible notes	24,368	24,411
Recognized loss on purchase commitments - long term	96,694	97,585
Deferred payments from collaboration - long term	437	500
Milestone rights liability	7,201	7,201
Total liabilities	285,085	299,307
Commitments and contingencies (Note 12)
Stockholders' deficit:
Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at March 31, 2018 and December 31, 2017
Common stock, $0.01 par value - 280,000,000 shares authorized, 126,013,051 and 119,053,414 shares issued and outstanding at March 31, 2018 and December 31, 2017, respectively	1,260	1,192
Additional paid-in capital	2,658,957	2,638,992
Accumulated other comprehensive loss	(15)	(18)
Accumulated deficit	(2,883,410)	(2,854,898)
Total stockholders' deficit	(223,208)	(214,732)
Total liabilities and stockholders' deficit	$ 61,877	$ 84,575