Fair value of financial instruments.

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- Definition

Fair value of liability, percentage decrease.

+ References

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Fair value of liability percentage decrease if probabilities of meeting milestones percentage decrease.

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Probabilities of meeting milestones amount.

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Probabilities of meeting milestones, percentage decrease.

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- Definition

Measure of dispersion, in percentage terms (for instance, the standard deviation or variance), for a given stock price.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (bbb)
-URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258

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- Definition

Risk-free interest rate assumption used in valuing an instrument.

+ References

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Interest rate used to find the present value of an amount to be paid or received in the future as an input to measure fair value. For example, but not limited to, weighted average cost of capital (WACC), cost of capital, cost of equity and cost of debt.

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- Definition

Fair value of financial and nonfinancial obligations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258

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Investment in short-term money-market instruments (such as commercial paper, banker's acceptances, repurchase agreements, government securities, certificates of deposit, and so forth) which are highly liquid (that is, readily convertible to known amounts of cash) and so near their maturity that they present an insignificant risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify as cash equivalents by definition. Original maturity means an original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three-years ago does not become a cash equivalent when its remaining maturity is three months.

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- Definition

Amount of long-term debt classified as other, payable after one year or the operating cycle, if longer.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.22)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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Fair Value of Financial Instruments - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Jul. 01, 2013
Fair Value Of Financial Instruments [Line Items]
Cash equivalents, money market funds	$ 41,000,000	$ 20,500,000
Fair value of the liability, percentage decrease	4.00%
Milestone Rights Liability \| Deerfield
Fair Value Of Financial Instruments [Line Items]
Long term liability	$ 8,900,000
Minimum
Fair Value Of Financial Instruments [Line Items]
Probabilities of meeting the milestones, amount	$ 50,000,000
Probabilities of meeting the milestones, percentage decrease	5.00%
Fair value of the liability, percentage decrease	14.00%
Maximum
Fair Value Of Financial Instruments [Line Items]
Probabilities of meeting the milestones, amount	$ 200,000,000
Probabilities of meeting the milestones, percentage decrease	10.00%
Fair value of the liability, percentage decrease	28.00%
Senior convertible notes due December 31, 2019 \| Milestone Rights Liability \| Deerfield
Fair Value Of Financial Instruments [Line Items]
Long term liability	$ 7,200,000	$ 8,900,000	$ 13,100,000
Fair Value, Inputs, Level 3 \| Milestone Rights Liability
Fair Value Of Financial Instruments [Line Items]
Fair value of warrants liability	$ 19,100,000
Fair Value, Inputs, Level 3 \| Market Approach Valuation Technique \| 5.75% Senior convertible notes due October 23, 2021 \| Senior Convertible Notes
Fair Value Of Financial Instruments [Line Items]
Fair value assumption, risk-free rate	20.00%
Fair value assumption, stock price volatility	102.00%
Fair Value, Inputs, Level 3 \| Income Approach Valuation Technique \| Milestone Rights Liability
Fair Value Of Financial Instruments [Line Items]
Market discount rate	14.00%
Fair Value, Inputs, Level 3 \| Income Approach Valuation Technique \| Senior convertible notes due December 31, 2019 \| Minimum
Fair Value Of Financial Instruments [Line Items]
Market discount rate	12.00%
Fair Value, Inputs, Level 3 \| Income Approach Valuation Technique \| Senior convertible notes due December 31, 2019 \| Maximum
Fair Value Of Financial Instruments [Line Items]
Market discount rate	13.00%