Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues:
Net revenue - commercial product sales	$ 9,192	$ 1,895
Net revenue - collaboration	250	171,965
Revenue - other	2,303	898
Total revenues	11,745	174,758
Expenses:
Cost of goods sold	17,228	17,121	$ 64,745
Cost of revenue - collaboration		32,971
Research and development	14,118	14,917	29,674
Selling, general and administrative	74,959	46,928	40,960
Property and equipment impairment	203	1,259	140,412
Loss (gain) on foreign currency translation	13,641	(3,433)	2,697
(Gain) loss on purchase commitments	(215)	(2,265)	66,167
Total expenses	119,934	107,498	344,655
(Loss) income from operations	(108,189)	67,260	(344,655)
Other (expense) income:
Change in fair value of warrant liability	5,488	5,369
Interest income	293	85	18
Interest expense on notes	(9,494)	(15,576)	(21,231)
Interest expense on note payable to principal stockholder	(3,782)	(2,901)	(2,894)
(Loss) gain on extinguishment of debt	(1,611)	72,024	(1,049)
Other income (expense)	13	(597)	1,366
Total other (expense) income	(9,093)	58,404	(23,790)
(Loss) income before income tax expense	(117,282)	125,664	(368,445)
Provision for income taxes	51
Net (loss) income	$ (117,333)	$ 125,664	$ (368,445)
Net (loss) income per share - basic	$ (1.13)	$ 1.37	$ (4.54)
Net (loss) income per share - diluted	$ (1.13)	$ 1.36	$ (4.54)
Shares used to compute basic net (loss) income per share	104,245	92,053	81,233
Shares used to compute diluted net (loss) income per share	104,245	92,085	81,233