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Fair Value of Financial Instruments - Additional Information (Detail)
$ in Millions
9 Months Ended 12 Months Ended
Sep. 29, 2017
WarrantHolder
shares
Sep. 29, 2017
shares
WarrantHolder
Sep. 30, 2017
USD ($)
Dec. 31, 2016
USD ($)
May 12, 2016
USD ($)
Fair Value of Financial Instruments [Line Items]          
Cash equivalents, money market funds     $ 18.4 $ 20.5  
Warrants issued, fair value         $ 12.8
Number of warrant holders | shares   4      
Fair value of the liability, percentage decrease     7.00%    
Minimum          
Fair Value of Financial Instruments [Line Items]          
Probabilities of meeting the milestones, percentage decrease     5.00%    
Fair value of the liability, percentage decrease     16.00%    
Maximum          
Fair Value of Financial Instruments [Line Items]          
Probabilities of meeting the milestones, percentage decrease     10.00%    
Fair value of the liability, percentage decrease     30.00%    
Milestone Rights Liability | Deerfield          
Fair Value of Financial Instruments [Line Items]          
Long term liability     $ 8.9    
Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Deerfield          
Fair Value of Financial Instruments [Line Items]          
Long term liability     7.2 8.9  
Warrant Liability          
Fair Value of Financial Instruments [Line Items]          
Fair value of warrants liability       $ 7.4  
Valuation technique       Monte Carlo valuation pricing model  
Fair value assumption, risk-free rate       1.14%  
Warrant liability fair value assumptions, dividend yield       0.00%  
Warrant liability fair value assumptions, remaining term       1 year 4 months 25 days  
Fair value assumption, stock price volatility       118.00%  
Fair Value, Inputs, Level 3 | Milestone Rights Liability          
Fair Value of Financial Instruments [Line Items]          
Fair value of warrants liability     $ 18.7    
Fair Value, Inputs, Level 3 | Market Approach Valuation Technique | 5.75% Senior convertible notes due August 15, 2018 | Senior Convertible Notes          
Fair Value of Financial Instruments [Line Items]          
Fair value assumption, risk-free rate     20.00%    
Fair value assumption, stock price volatility     107.00%    
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019          
Fair Value of Financial Instruments [Line Items]          
Market discount rate     12.00%    
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability          
Fair Value of Financial Instruments [Line Items]          
Market discount rate     14.00%    
Warrant Exchange Agreement          
Fair Value of Financial Instruments [Line Items]          
Number of warrant holders | WarrantHolder 4 4      
Outstanding warrants | shares 9,700,000 9,700,000