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Facility Agreement - Additional Information (Detail) - USD ($)
3 Months Ended 12 Months Ended
Jul. 01, 2013
Mar. 31, 2015
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Debt Instrument [Line Items]          
Facility Agreement, total principle payment in 2016     $ 5,000,000    
Facility Agreement, total principle payment in 2017     20,000,000    
Facility Agreement, total principle payment in 2018     20,000,000    
Facility Agreement, total principle payment in 2019     35,000,000    
Short term liability     74,582,000 $ 72,995,000  
Interest expense on notes     21,231,000 17,549,000 $ 15,153,000
Sanofi-Aventis Deutschland GmbH          
Debt Instrument [Line Items]          
Carrying value     $ 44,500,000 3,000,000  
Deerfield          
Debt Instrument [Line Items]          
Principal repayment schedule, start date     Jul. 01, 2016    
Principal repayment schedule, end date     Dec. 09, 2019    
Deerfield | Senior convertible notes due December 31, 2019          
Debt Instrument [Line Items]          
Debt facility principal amount     $ 60,000,000 60,000,000  
Senior notes, effective interest rate     9.75%    
Deerfield | Senior convertible notes due December 31, 2019 | Facility Agreement          
Debt Instrument [Line Items]          
Uncreated debt discount     $ 5,300,000    
Uncreated debt issuance cost     100,000    
Deerfield | Less portion of commitment asset | Senior convertible notes due December 31, 2019          
Debt Instrument [Line Items]          
Debt facility principal amount     $ 20,000,000 20,000,000  
Senior notes, effective interest rate     8.75%    
Deerfield | Less portion of commitment asset | Minimum | Senior convertible notes due December 31, 2019 | Facility Agreement          
Debt Instrument [Line Items]          
Available amount of credit facility under covenant restrictions     $ 25,000,000    
Deerfield | Milestone Rights Liability | Senior convertible notes due December 31, 2019          
Debt Instrument [Line Items]          
Short term liability $ 3,200,000        
Long term liability $ 13,100,000   8,900,000    
Interest expense on notes   $ 5,800,000      
Required payment pursuant to the terms of the Milestone Agreement   $ 10,000,000      
Discount rate 17.50%        
Risk premium 5.00%        
Fair value of milestone rights $ 16,300,000        
Deerfield | Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Sanofi-Aventis Deutschland GmbH          
Debt Instrument [Line Items]          
Interest expense on notes       1,900,000  
Required payment pursuant to the terms of the Milestone Agreement       $ 5,000,000  
Deerfield | Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Danbury Facility          
Debt Instrument [Line Items]          
Carrying value     $ 23,000,000    
Deerfield | Milestone Rights Liability | Maximum          
Debt Instrument [Line Items]          
Contingent liability for milestone payments $ 90,000,000