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Collaborative Arrangement - Additional Information (Detail) - USD ($)
3 Months Ended 12 Months Ended
Feb. 10, 2016
Jan. 04, 2016
Aug. 11, 2014
Sep. 30, 2014
Dec. 31, 2015
Dec. 31, 2014
Sep. 23, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Paid-in-kind interest         $ 1,652,000    
Sanofi-Aventis Deutschland GmbH              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Carrying value         44,500,000 $ 3,000,000  
Sanofi-Aventis Deutschland GmbH | CALIFORNIA              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Carrying value         $ 17,900,000    
License and Collaboration Agreement with Sanofi              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Up-front fee       $ 150,000,000      
Potential milestone payment     $ 775,000,000        
Profits and losses sharing percentage     35.00%   35.00%    
Maximum secured loan facility             $ 175,000,000
Senior notes, effective interest rate             8.50%
License and Collaboration Agreement with Sanofi | Subsequent Event              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Termination date   Jul. 04, 2016          
License and Collaboration Agreement with Sanofi | Manufacturing Milestone Events              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestone payments earned           $ 50,000,000  
License and Collaboration Agreement with Sanofi | Development Milestone Event              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential milestone payment     $ 75,000,000        
License and Collaboration Agreement with Sanofi | Regulatory Approvals              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential milestone payment     50,000,000        
License and Collaboration Agreement with Sanofi | Product Sales Milestones              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential milestone payment     $ 650,000,000        
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Up-front fee         $ 150,000,000    
Profits and losses sharing percentage     65.00%   65.00%    
Deferred revenue from collaboration product shipments         $ 150,000,000    
Milestone receivable         50,000,000    
Deferred cost         13,500,000    
Company's total portion of loss sharing         57,700,000    
Maximum secured loan facility         175,000,000    
Carrying value         44,500,000    
Secured loan facility, amount borrowed         44,500,000    
Secured loan facility, amount owed         62,400,000    
Paid-in-kind interest         1,700,000    
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | Subsequent Event              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Secured loan facility, amount borrowed $ 17,900,000            
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | Operating loss Sharing              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Company's total portion of loss sharing         60,700,000    
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | AFREZZA product sales              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Deferred revenue from collaboration product shipments         $ 17,500,000