Property and Equipment - Additional Information (Detail) $ in Thousands		12 Months Ended
	Jan. 04, 2016	Dec. 31, 2015 USD ($) asset_group	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)
Depreciation and Other Amortization Expenses [Line Items]
Amortization period of lease hold improvements		4 years
Depreciation and amortization expense		$ 11,000	$ 9,800	$ 11,500
Number of primary asset groups | asset_group		2
Impairment charge		$ 242,700
Danbury Facility
Depreciation and Other Amortization Expenses [Line Items]
Impairment charge		138,600
Valencia
Depreciation and Other Amortization Expenses [Line Items]
Impairment charge		$ 1,800
Subsequent Event | License and Collaboration Agreement with Sanofi
Depreciation and Other Amortization Expenses [Line Items]
Termination date	Jul. 04, 2016