Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue	$ 0	$ 0	$ 0
Operating expenses:
Research and development	29,674	100,244	109,719
General and administrative	40,960	79,383	59,682
Product manufacturing	67,442
Property and equipment impairment	140,412	0	0
Loss on purchase commitments	66,167
Total operating expenses	344,655	179,627	169,401
Loss from operations	(344,655)	(179,627)	(169,401)
Other income (expense)	1,366	1,679	(635)
Loss on extinguishment of debt	(1,049)
Interest expense on note payable to principal stockholder	(2,894)	(2,894)	(6,309)
Interest expense on notes	(21,231)	(17,549)	(15,153)
Interest income	18	9	8
Loss before benefit for income taxes	(368,445)	(198,382)	(191,490)
Income tax benefit	0	0	0
Net loss	$ (368,445)	$ (198,382)	$ (191,490)
Net loss per share - basic and diluted	$ (0.91)	$ (0.51)	$ (0.64)
Shares used to compute basic and diluted net loss per share	406,165	385,229	299,591