Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	12 Months Ended			263 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2012
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (169,366)	$ (160,804)	$ (170,560)	$ (2,104,912)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and accretion	14,402	15,912	17,324	126,777
Stock-based compensation expense	13,292	11,204	13,580	137,918
Stock expense for shares issued pursuant to research agreement				3,018
Loss (gain) on sale, abandonment/disposal or impairment of property and equipment	682	(4)		24,253
Accrued interest on investments, net of amortization of premiums (discounts)				(191)
In-process research and development				19,726
Goodwill impairment				151,428
Loss on available-for-sale securities	117		644	990
Fair value of forward purchase contract	1,237			1,237
Common shares issued pursuant to litigation settlement	438			438
Commitment to deliver common shares pursuant to litigation settlement	6,056			6,056
Other, net	(2)	(3)	(6)	1,099
Changes in assets and liabilities:
State research and development credit exchange receivable	(290)	830	1,115	(763)
Prepaid expenses and other current assets	(1,545)	224	823	(2,570)
Other assets		87	267	(230)
Accounts payable	44	2,672	(4,287)	4,418
Accrued expenses and other current liabilities	15,075	6,045	(7,554)	35,049
Other liabilities				(2)
Net cash used in operating activities	(119,860)	(123,837)	(148,654)	(1,596,261)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchase of marketable securities			(4,178)	(796,779)
Sales and maturities of marketable securities		3,828	2,000	796,393
Purchase of property and equipment	(637)	(6,858)	(9,542)	(327,746)
Proceeds from sale of property and equipment	77	93		454
Net cash used in investing activities	(560)	(2,937)	(11,720)	(327,678)
CASH FLOWS FROM FINANCING ACTIVITIES:
Issuance of common stock and warrants for cash	167,735	10,941	17,025	1,397,756
Collection of Series C convertible preferred stock subscriptions receivable				50,000
Issuance of Series B convertible preferred stock for cash				15,000
Cash received for common stock to be issued				3,900
Repurchase of common stock				(1,028)
Put shares sold to majority stockholder				623
Borrowings under lines of credit				4,220
Proceeds from notes receivables				1,742
Borrowings on notes payable from related party	12,750	53,000	87,000	387,750
Principal payments on notes payable to principal stockholder				(70,000)
Borrowings on notes payable				3,460
Principal payments on notes payable				(1,667)
Proceeds from senior convertible notes			95,783	207,050
Payment of employment taxes related to vested restricted stock units	(906)	(547)	(3,392)	(13,027)
Net cash provided by financing activities	179,579	63,394	196,416	1,985,779
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	59,159	(63,380)	36,042	61,840
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD	2,681	66,061	30,019
CASH AND CASH EQUIVALENTS, END OF PERIOD	61,840	2,681	66,061	61,840
SUPPLEMENTAL CASH FLOWS DISCLOSURES:
Cash paid for income taxes				26
Interest paid in cash, net of amounts capitalized to Construction in progress	9,755	17,248	13,662	59,152
Accretion on redeemable convertible preferred stock				(952)
Issuance of common stock upon conversion of notes payable				3,331
Increase in additional paid-in capital resulting from merger				171,154
Issuance of common stock for notes receivable				2,758
Issuance of put option by stockholder				(2,949)
Put option redemption by stockholder				1,921
Issuance of Series C convertible preferred stock subscriptions				50,000
Issuance of Series A redeemable convertible preferred stock				4,296
Conversion of Series A redeemable convertible preferred stock				(5,248)
Non-cash construction in progress and property and equipment	4,072	250	1,742	4,072
Capitalization of interest on note payable to related party	14,219			14,219
Reduction of principal on note payable to related party upon issuance of common stock and warrants	184,537	11,116	16,681	212,334
Forward purchase contracts contribution to additional paid-in capital	29,317			29,317
Reclassification of forward purchase contracts to additional paid-in capital	$ 28,080			$ 28,080