Collaboration, Licensing and Other Arrangements - Summary of UT Revenue (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total revenue from UT	$ 70,079	$ 51,253	$ 208,728	$ 140,490
United Therapeutics Corporation
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total revenue from UT	50,314	33,289	149,346	86,546
United Therapeutics Corporation | Commercial Supply
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total revenue from UT	23,231	12,800	73,673	34,897
United Therapeutics Corporation | License Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total revenue from UT		271	347	698
United Therapeutics Corporation | Royalties Arrangement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total revenue from UT	$ 27,083	$ 20,218	$ 75,326	$ 50,951