XML 72 R65.htm IDEA: XBRL DOCUMENT v3.24.1.u1
Collaboration, Licensing and Other Arrangements - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Oct. 31, 2018
Dec. 31, 2023
Dec. 31, 2022
May 31, 2018
Mar. 31, 2024
Mar. 31, 2023
Dec. 31, 2023
Feb. 28, 2023
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Deferred revenue - current   $ 9,085,000     $ 7,601,000   $ 9,085,000  
Deferred revenue - non-current   $ 69,794,000     67,741,000   69,794,000  
Total revenue from UT         66,263,000 $ 40,626,000    
Collaborations and services                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Total revenue from UT         24,848,000 11,386,000    
AFREZZA product sales                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Total revenue from UT         18,764,000 17,562,000    
United Therapeutics Corporation                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Total revenue from UT         47,462,000 23,027,000    
United Therapeutics Corporation | Manufacturing Services                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Funding for development of alternative manufacturing processes     $ 2,300,000          
United Therapeutics Corporation | Commercialization and Continuous Improvement Activities                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Funding for capital improvements     39,500,000          
Thirona Bio, Inc.                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Minimum amount to expended               $ 1,100,000
Funded amount         900,000      
Collaboration and License Agreement | United Therapeutics Corporation                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Total anticipated cash flows [1]     722,300,000          
Deferred revenue         74,000,000 77,500,000    
Deferred revenue - current         7,400,000 8,900,000    
Deferred revenue - non-current         $ 66,600,000 68,600,000    
Royalty percentage 10.00%              
Royalty future net sales percentage   1.00%            
Royalty retaining percentage   9.00%            
License agreement description         There have been various amendments to the UT License Agreement and the CSA since inception. As amended, the term of the CSA continues until December 31, 2031 (unless earlier terminated) and is thereafter renewed automatically for additional, successive two-year terms unless (i) UT provides notice to the Company at least 24 months in advance of such renewal that UT does not wish to renew the CSA or (ii) the Company provides notice to UT at least 48 months in advance of such renewal that the Company does not wish to renew the CSA      
Collaboration and License Agreement | United Therapeutics Corporation | Manufacturing Services                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Total anticipated cash flows     722,300,000          
Collaboration and License Agreement | United Therapeutics Corporation | Next-Gen R&D Services | Transaction Price For The Performance Obligations                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Total anticipated cash flows     $ 602,300,000          
Commercial Supply Agreement | United Therapeutics Corporation | Collaborations and services                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Total revenue from UT         $ 24,464,000 11,164,000    
Supply and Distribution Agreement | AFREZZA product sales | Biomm                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Total revenue from UT         0   $ 0  
License and Distribution Agreement | Cipla Ltd                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Deferred revenue         1,300,000 1,400,000    
Deferred revenue - current         100,000 200,000    
Deferred revenue - non-current         1,200,000 1,200,000    
Marketing and distribution agreement date       2018-05        
License and Distribution Agreement | Collaborations and services | Cipla Ltd                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Total revenue from UT         $ 37,000 $ 37,000    
[1] The total anticipated cash flow includes a transaction price of $120.0 million for the contractual obligations under the CSA for the Manufacturing Services and Product Sales and the Next-Gen R&D Services performance obligations and $602.3 million for future supply of Tyvaso DPI over the remaining term of the CSA.