Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Deferred tax assets:
Net operating loss carryforwards	$ 506,641	$ 542,537
Research and development credits	77,007	78,804
Capitalized research costs	14,225	4,369
Milestone Rights	1,006	1,331
Accrued expenses	3,760	2,675
Loss on purchase commitment	22,806	23,117
Non-qualified stock option expense	3,559	7,686
Capitalized patent costs	6,720	8,058
Other	3,405	3,204
Lease liability	1,280	1,624
Interest expense limitation	2,782	10,991
Depreciation	21,134	22,157
Deferred product revenue and costs	346	370
Sale of future royalties	34,848
Total deferred tax assets	699,519	706,923
Valuation allowance	(698,228)	(705,034)
Net deferred tax assets	1,291	1,889
Deferred tax liabilities:
Right of use asset	(1,121)	(1,640)
Other prepaids	(176)	(249)
Total deferred tax liabilities	(1,297)	$ (1,889)
Net deferred tax assets	$ (6)