Condensed Consolidated Statements of Stockholders' Deficit - USD ($) shares in Thousands, $ in Thousands	Total	Convertible Note The Mann Group L L C	Convertible Note Interest The Mann Group L L C	At-the-market Placement	Common Stock	Common Stock Convertible Note The Mann Group L L C	Common Stock Convertible Note Interest The Mann Group L L C	Common Stock At-the-market Placement	Additional Paid-in Capital	Additional Paid-in Capital Convertible Note The Mann Group L L C	Additional Paid-in Capital Convertible Note Interest The Mann Group L L C	Additional Paid-in Capital At-the-market Placement	Accumulated Other Comprehensive Loss	Accumulated Deficit
Beginning Balance at Dec. 31, 2021	$ (209,349)				$ 2,515				$ 2,918,205					$ (3,130,069)
Beginning Balance (in shares) at Dec. 31, 2021					251,478
Net issuance of common stock associated with stock options and restricted stock units	129				$ 4				125
Net issuance of common stock associated with stock options and restricted stock units (in shares)					450
Issuance of common stock under the employee stock purchase plan	740				$ 2				738
Issuance of common stock under the employee stock purchase plan (in shares)					233
Stock-based compensation expense	2,806								2,806
Issuance of common stock from market price stock purchase plan	684				$ 3				681
Issuance of common stock from Market Price Stock Purchase Plan (in shares)					252
Cumulative gain (loss) on available-for-sale securities	(1,076)												$ (1,076)
Net Income (Loss)	(25,998)													(25,998)
Ending Balance at Mar. 31, 2022	(232,064)				$ 2,524				2,922,555				(1,076)	(3,156,067)
Ending Balance (in shares) at Mar. 31, 2022					252,413
Beginning Balance at Dec. 31, 2021	(209,349)				$ 2,515				2,918,205					(3,130,069)
Beginning Balance (in shares) at Dec. 31, 2021					251,478
Net Income (Loss)	(55,021)
Ending Balance at Jun. 30, 2022	(247,056)				$ 2,573				2,936,667				(1,206)	(3,185,090)
Ending Balance (in shares) at Jun. 30, 2022					257,277
Beginning Balance at Mar. 31, 2022	(232,064)				$ 2,524				2,922,555				(1,076)	(3,156,067)
Beginning Balance (in shares) at Mar. 31, 2022					252,413
Net issuance of common stock associated with stock options and restricted stock units	(377)				$ 8				(385)
Net issuance of common stock associated with stock options and restricted stock units (in shares)					833
Stock-based compensation expense	4,422								4,422
Issuance of common stock pursuant to conversion notes		$ 9,596	$ 520			$ 39	$ 2			$ 9,557	$ 518
Issuance of common stock pursuant to conversion notes (in shares)						3,838	193
Cumulative gain (loss) on available-for-sale securities	(130)												(130)
Net Income (Loss)	(29,023)													(29,023)
Ending Balance at Jun. 30, 2022	(247,056)				$ 2,573				2,936,667				(1,206)	(3,185,090)
Ending Balance (in shares) at Jun. 30, 2022					257,277
Beginning Balance at Dec. 31, 2022	(250,538)				$ 2,638				2,964,293					(3,217,469)
Beginning Balance (in shares) at Dec. 31, 2022					263,793
Net issuance of common stock associated with stock options and restricted stock units	52				$ 2				50
Net issuance of common stock associated with stock options and restricted stock units (in shares)					206
Stock-based compensation expense	3,655								3,655
Issuance of common stock pursuant to conversion notes			55								55
Issuance of common stock pursuant to conversion notes (in shares)							11
Issuance of common stock associated with at-the-market placement				$ 1,199				$ 3				$ 1,196
Issuance of common stock associated with at-the-market placement (in shares)								269
Issuance costs associated with at-the- market placement	(24)								(24)
Net Income (Loss)	(9,795)													(9,795)
Ending Balance at Mar. 31, 2023	(255,396)				$ 2,643				2,969,225					(3,227,264)
Ending Balance (in shares) at Mar. 31, 2023					264,279
Beginning Balance at Dec. 31, 2022	(250,538)				$ 2,638				2,964,293					(3,217,469)
Beginning Balance (in shares) at Dec. 31, 2022					263,793
Net Income (Loss)	(15,060)
Ending Balance at Jun. 30, 2023	(260,487)				$ 2,682				2,968,917				443	(3,232,529)
Ending Balance (in shares) at Jun. 30, 2023					268,235
Beginning Balance at Mar. 31, 2023	(255,396)				$ 2,643				2,969,225					(3,227,264)
Beginning Balance (in shares) at Mar. 31, 2023					264,279
Net issuance of common stock associated with stock options and restricted stock units	(8,544)				$ 32				(8,576)
Net issuance of common stock associated with stock options and restricted stock units (in shares)					3,279
Issuance of common stock under the employee stock purchase plan	923				$ 3				920
Issuance of common stock under the employee stock purchase plan (in shares)					266
Stock-based compensation expense	5,580								5,580
Issuance of common stock pursuant to conversion notes			$ 54								$ 54
Issuance of common stock pursuant to conversion notes (in shares)							13
Issuance of common stock from market price stock purchase plan	152								152
Issuance of common stock from Market Price Stock Purchase Plan (in shares)					36
Cumulative gain (loss) on available-for-sale securities	443												443
Issuance of common stock associated with at-the-market placement				$ 1,583				$ 4				$ 1,579
Issuance of common stock associated with at-the-market placement (in shares)								362
Issuance costs associated with at-the- market placement	(17)								(17)
Net Income (Loss)	(5,265)													(5,265)
Ending Balance at Jun. 30, 2023	$ (260,487)				$ 2,682				$ 2,968,917				$ 443	$ (3,232,529)
Ending Balance (in shares) at Jun. 30, 2023					268,235