Vaxcyte, Inc.

NPORT-P false 0000899148 XXXXXXXX S000003802 C000010594 C000010597 C000010596 C000010595 Rydex Series Funds 811-07584 0000899148 5493004D62WV1EDNTU07 702 King Farm Blvd., Suite 200 Rockville 20850 301-296-5100 Biotechnology Fund S000003802 549300YENG103R306541 2025-03-31 2024-12-31 N 91897231.92 190309.05 91706922.87 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 N Vaxcyte Inc 254900M7NMHTGASX8D95 Vaxcyte, Inc. 92243G108 15306.00000000 NS USD 1252949.16000000 1.366253627085 Long EC CORP US N 1 N N N Krystal Biotech Inc 549300YONUY68210OE41 Krystal Biotech, Inc. 501147102 2988.00000000 NS USD 468100.08000000 0.510430472804 Long EC CORP US N 1 N N N Biogen Inc W8J5WZB5IY3K0NDQT671 Biogen, Inc. 09062X103 12812.00000000 NS USD 1959211.04000000 2.136382923650 Long EC CORP US N 1 N N N Veracyte Inc 529900ESWZRHXOW27Z37 Veracyte, Inc. 92337F107 17192.00000000 NS USD 680803.20000000 0.742368382553 Long EC CORP US N 1 N N N Celldex Therapeutics Inc 529900F018DMYWH38923 Celldex Therapeutics, Inc. 15117B202 20934.00000000 NS USD 529002.18000000 0.576839963052 Long EC CORP US N 1 N N N Dyne Therapeutics Inc N/A Dyne Therapeutics, Inc. 26818M108 20044.00000000 NS USD 472236.64000000 0.514941102831 Long EC CORP US N 1 N N N Ionis Pharmaceuticals Inc 549300SI4ZGLG0BLUZ92 Ionis Pharmaceuticals, Inc. 462222100 26764.00000000 NS USD 935669.44000000 1.020282232483 Long EC CORP US N 1 N N N Argenx SE 7245009C5FZE6G9ODQ71 Argenx SE 04016X101 1885.00000000 NS USD 1159275.00000000 1.264108492270 Long EC CORP NL N 1 N N N Summit Therapeutics Inc N/A Summit Therapeutics, Inc. 86627T108 32604.00000000 NS USD 581818.38000000 0.634432343591 Long EC CORP US N 1 N N N J.P. MORGAN SECURITIES LLC ZBUT11V806EZRVTWT807 J.P. Morgan Securities LLC N/A 199423.00000000 PA USD 199423.00000000 0.217456865587 Long RA CORP US N 2 Repurchase Y 4.45000000 2025-01-02 225862.55000000 USD 203411.54000000 USD UST N N N TG Therapeutics Inc 529900X21UKABN9NJ529 TG Therapeutics, Inc. 88322Q108 28050.00000000 NS USD 844305.00000000 0.920655686154 Long EC CORP US N 1 N N N Arcellx Inc N/A Arcellx, Inc. 03940C100 7136.00000000 NS USD 547259.84000000 0.596748667247 Long EC CORP US N 1 N N N Twist Bioscience Corp 549300T23BL59LCOH584 Twist Bioscience Corp. 90184D100 14484.00000000 NS USD 673071.48000000 0.733937481420 Long EC CORP US N 1 N N N Sarepta Therapeutics Inc 549300IKDPIED8J8IG21 Sarepta Therapeutics, Inc. 803607100 11342.00000000 NS USD 1379073.78000000 1.503783724108 Long EC CORP US N 1 N N N AstraZeneca PLC PY6ZZQWO2IZFZC3IOL08 AstraZeneca plc 046353108 31482.00000000 NS USD 2062700.64000000 2.249231110855 Long EC CORP GB N 1 N N N Gilead Sciences Inc 549300WTZWR07K8MNV44 Gilead Sciences, Inc. 375558103 48297.00000000 NS USD 4461193.89000000 4.864620631011 Long EC CORP US N 1 N N N Neurocrine Biosciences Inc 549300FECER0XBN49756 Neurocrine Biosciences, Inc. 64125C109 11719.00000000 NS USD 1599643.50000000 1.744299612219 Long EC CORP US N 1 N N N Illumina Inc SQ95QG8SR5Q56LSNF682 Illumina, Inc. 452327109 13691.00000000 NS USD 1829528.33000000 1.994972977769 Long EC CORP US N 1 N N N Viatris Inc 254900ZZTSW7NL773X71 Viatris, Inc. 92556V106 124383.00000000 NS USD 1548568.35000000 1.688605725213 Long EC CORP US N 1 N N N Vertex Pharmaceuticals Inc 54930015RAQRRZ5ZGJ91 Vertex Pharmaceuticals, Inc. 92532F100 9901.00000000 NS USD 3987132.70000000 4.347689983723 Long EC CORP US N 1 N N N REVOLUTION Medicines Inc 549300JU3X0LBCQ65892 REVOLUTION Medicines, Inc. 76155X100 25478.00000000 NS USD 1114407.72000000 1.215183854309 Long EC CORP US N 1 N N N Protagonist Therapeutics Inc N/A Protagonist Therapeutics, Inc. 74366E102 12753.00000000 NS USD 492265.80000000 0.536781504159 Long EC CORP US N 1 N N N BOFA SECURITIES, INC. 549300HN4UKV1E2R3U73 BofA Securities, Inc. N/A 156754.56000000 PA USD 156754.56000000 0.170929909208 Long RA CORP US N 2 Repurchase Y 4.43000000 2025-01-02 172554.17000000 USD 159889.68000000 USD UST N N N Medpace Holdings Inc 549300H8TYEUVTW14A54 Medpace Holdings, Inc. 58506Q109 2920.00000000 NS USD 970111.60000000 1.057839004559 Long EC CORP US N 1 N N N Regeneron Pharmaceuticals Inc 549300RCBFWIRX3HYQ56 Regeneron Pharmaceuticals, Inc. 75886F107 5038.00000000 NS USD 3588718.54000000 3.913247143933 Long EC CORP US N 1 N N N Apellis Pharmaceuticals Inc 254900HS0ZFRXXSB9D42 Apellis Pharmaceuticals, Inc. 03753U106 24192.00000000 NS USD 771966.72000000 0.841775839643 Long EC CORP US N 1 N N N Beam Therapeutics Inc N/A Beam Therapeutics, Inc. 07373V105 20305.00000000 NS USD 503564.00000000 0.549101402861 Long EC CORP US N 1 N N N Recursion Pharmaceuticals Inc N/A Recursion Pharmaceuticals, Inc. 75629V104 94302.00000000 NS USD 637481.52000000 0.695129113538 Long EC CORP US N 1 N N Ascendis Pharma A/S 549300B66JN3W3J8GH73 Ascendis Pharma A/S 04351P101 3761.00000000 NS USD 517776.87000000 0.564599545809 Long EC CORP DK N 1 N N N Legend Biotech Corp 254900EIUFZTW136H859 Legend Biotech Corp. 52490G102 29868.00000000 NS USD 971904.72000000 1.059794276793 Long EC CORP KY N 1 N N N Alkermes PLC N/A Alkermes plc N/A 34838.00000000 NS USD 1001940.88000000 1.092546613324 Long EC CORP US N 1 N N N ADMA Biologics Inc N/A ADMA Biologics, Inc. 000899104 46121.00000000 NS USD 790975.15000000 0.862503206133 Long EC CORP US N 1 N N N Ultragenyx Pharmaceutical Inc 529900EV44GVDN1DCX77 Ultragenyx Pharmaceutical, Inc. 90400D108 18197.00000000 NS USD 765547.79000000 0.834776444396 Long EC CORP US N 1 N N N BioNTech SE 894500UZJ5LG1F8J1U58 BioNTech SE 09075V102 8257.00000000 NS USD 940885.15000000 1.025969600281 Long EC CORP DE N 1 N N N Royalty Pharma PLC 549300FGFN7VOK8BZR03 Royalty Pharma plc N/A 59117.00000000 NS USD 1508074.67000000 1.644450192858 Long EC CORP US N 1 N N N Amgen Inc 62QBXGPJ34PQ72Z12S66 Amgen, Inc. 031162100 18507.00000000 NS USD 4823664.48000000 5.259869515890 Long EC CORP US N 1 N N N SpringWorks Therapeutics Inc N/A SpringWorks Therapeutics, Inc. 85205L107 17279.00000000 NS USD 624290.27000000 0.680744975910 Long EC CORP US N 1 N N N Amicus Therapeutics Inc 549300MRD1SMUTNBPQ53 Amicus Therapeutics, Inc. 03152W109 71348.00000000 NS USD 672098.16000000 0.732876143879 Long EC CORP US N 1 N N N Cytokinetics Inc 549300BE5DY1HW7IHA64 Cytokinetics, Inc. 23282W605 20315.00000000 NS USD 955617.60000000 1.042034308963 Long EC CORP US N 1 N N N Insmed Inc 529900Q55QAG41CCAC11 Insmed, Inc. 457669307 20566.00000000 NS USD 1419876.64000000 1.548276395679 Long EC CORP US N 1 N N N BeiGene Ltd 549300JFUK6FRD5MH739 BeiGene Ltd. 07725L102 4071.00000000 NS USD 751954.41000000 0.819953812064 Long EC CORP KY N 1 N N N ACADIA Pharmaceuticals Inc 529900O3044NO0PEA039 ACADIA Pharmaceuticals, Inc. 004225108 35302.00000000 NS USD 647791.70000000 0.706371645375 Long EC CORP US N 1 N N N Moderna Inc 549300EI6OKH5K5Q2G38 Moderna, Inc. 60770K107 37294.00000000 NS USD 1550684.52000000 1.690913260930 Long EC CORP US N 1 N N N First American Funds N/A First American Government Obligations Fund - Class X N/A 873141.56000000 NS USD 873141.56000000 0.952099942594 Long STIV RF US N 1 N N Halozyme Therapeutics Inc 529900242I3SV9AGM753 Halozyme Therapeutics, Inc. 40637H109 21195.00000000 NS USD 1013332.95000000 1.104968870710 Long EC CORP US N 1 N N N Ideaya Biosciences Inc 549300ULW08F62IJML11 Ideaya Biosciences, Inc. 45166A102 23738.00000000 NS USD 610066.60000000 0.665235056316 Long EC CORP US N 1 N N N Madrigal Pharmaceuticals Inc 549300CHIMT2EUSNJB60 Madrigal Pharmaceuticals, Inc. 558868105 1856.00000000 NS USD 572705.92000000 0.624495841837 Long EC CORP US N 1 N N N Exact Sciences Corp 549300VM3X1FYD4N9Z14 Exact Sciences Corp. 30063P105 21939.00000000 NS USD 1232752.41000000 1.344230480557 Long EC CORP US N 1 N N N Dynavax Technologies Corp 549300T5URIXWDILX594 Dynavax Technologies Corp. 268158201 41374.00000000 NS USD 528345.98000000 0.576124422742 Long EC CORP US N 1 N N N Immunovant Inc N/A Immunovant, Inc. 45258J102 20015.00000000 NS USD 495771.55000000 0.540604279900 Long EC CORP US N 1 N N N BioMarin Pharmaceutical Inc NSLL8ITTRR0J5HEMR848 BioMarin Pharmaceutical, Inc. 09061G101 22258.00000000 NS USD 1463018.34000000 1.595319409063 Long EC CORP US N 1 N N N Bridgebio Pharma Inc 54930028YG89VTY2J114 Bridgebio Pharma, Inc. 10806X102 31154.00000000 NS USD 854865.76000000 0.932171457995 Long EC CORP US N 1 N N N Intellia Therapeutics Inc 5493002T5BCPE5DZC723 Intellia Therapeutics, Inc. 45826J105 35611.00000000 NS USD 415224.26000000 0.452773080815 Long EC CORP US N 1 N N N Viking Therapeutics Inc 529900IVC72YPFA25M37 Viking Therapeutics, Inc. 92686J106 19483.00000000 NS USD 783995.92000000 0.854892842835 Long EC CORP US N 1 N N N Avidity Biosciences Inc N/A Avidity Biosciences, Inc. 05370A108 24298.00000000 NS USD 706585.84000000 0.770482552338 Long EC CORP US N 1 N N N Intra-Cellular Therapies Inc 5299002U2KGF193IJA20 Intra-Cellular Therapies, Inc. 46116X101 14407.00000000 NS USD 1203272.64000000 1.312084848496 Long EC CORP US N 1 N N N Roivant Sciences Ltd. N/A Roivant Sciences Ltd. N/A 81162.00000000 NS USD 960146.46000000 1.046972714765 Long EC CORP US N 1 N N N Arrowhead Pharmaceuticals Inc 549300O3CSB8T7OZ3D66 Arrowhead Pharmaceuticals, Inc. 04280A100 30893.00000000 NS USD 580788.40000000 0.633309222274 Long EC CORP US N 1 N N N AbbVie Inc FR5LCKFTG8054YNNRU85 AbbVie, Inc. 00287Y109 42051.00000000 NS USD 7472462.70000000 8.148199139330 Long EC CORP US N 1 N N N Blueprint Medicines Corp 5299004CC60O9T5HVM83 Blueprint Medicines Corp. 09627Y109 10085.00000000 NS USD 879613.70000000 0.959157359632 Long EC CORP US N 1 N N N Exelixis Inc 254900PJQB59O2O95R37 Exelixis, Inc. 30161Q104 36868.00000000 NS USD 1227704.40000000 1.338725977907 Long EC CORP US N 1 N N N Agios Pharmaceuticals Inc 529900ONJHY8EOGYT555 Agios Pharmaceuticals, Inc. 00847X104 11893.00000000 NS USD 390803.98000000 0.426144469544 Long EC CORP US N 1 N N N Iovance Biotherapeutics Inc 2549002L8WT2ACU5Q878 Iovance Biotherapeutics, Inc. 462260100 78174.00000000 NS USD 578487.60000000 0.630800360426 Long EC CORP US N 1 N N N Crinetics Pharmaceuticals Inc 549300Q1CNFXK5P31D28 Crinetics Pharmaceuticals, Inc. 22663K107 16466.00000000 NS USD 841906.58000000 0.918040376508 Long EC CORP US N 1 N N N Natera Inc N/A Natera, Inc. 632307104 11419.00000000 NS USD 1807627.70000000 1.971091868999 Long EC CORP US N 1 N N N PTC Therapeutics Inc 549300UJLWOIWFDGB318 PTC Therapeutics, Inc. 69366J200 16950.00000000 NS USD 765123.00000000 0.834313240544 Long EC CORP US N 1 N N N Guardant Health Inc 254900M8C3E5VC8BR186 Guardant Health, Inc. 40131M109 23844.00000000 NS USD 728434.20000000 0.794306664320 Long EC CORP US N 1 N N N Incyte Corp 549300Z4WN6JVZ3T4680 Incyte Corp. 45337C102 19725.00000000 NS USD 1362405.75000000 1.485608400503 Long EC CORP US N 1 N N N Corteva Inc 549300WZN9I2QKLS0O94 Corteva, Inc. 22052L104 44623.00000000 NS USD 2541726.08000000 2.771574926358 Long EC CORP US N 1 N N N Denali Therapeutics Inc 549300ZTQ2HO18L3Q830 Denali Therapeutics, Inc. 24823R105 29210.00000000 NS USD 595299.80000000 0.649132891356 Long EC CORP US N 1 N N N Alnylam Pharmaceuticals Inc 529900S3ZI14OWRJII50 Alnylam Pharmaceuticals, Inc. 02043Q107 9408.00000000 NS USD 2213796.48000000 2.413990580774 Long EC CORP US N 1 N N N Nuvalent Inc N/A Nuvalent, Inc. 670703107 7513.00000000 NS USD 588117.64000000 0.641301247053 Long EC CORP US N 1 N N N United Therapeutics Corp 5299005C4HZL4UWROC14 United Therapeutics Corp. 91307C102 4187.00000000 NS USD 1477341.08000000 1.610937357580 Long EC CORP US N 1 N N N Axsome Therapeutics Inc 549300EXGR0XLRJEIB95 Axsome Therapeutics, Inc. 05464T104 8112.00000000 NS USD 686356.32000000 0.748423672412 Long EC CORP US N 1 N N N Novavax Inc 529900J4GJHPEPQ23205 Novavax, Inc. 670002401 52822.00000000 NS USD 424688.88000000 0.463093588476 Long EC CORP US N 1 N N N CRISPR Therapeutics AG 506700O6IRRIQLT3W370 CRISPR Therapeutics AG N/A 21407.00000000 NS USD 842579.52000000 0.918774170620 Long EC CORP US N 1 N N Geron Corp 549300T282D7Z2YESL90 Geron Corp. 374163103 163968.00000000 NS USD 580446.72000000 0.632936644077 Long EC CORP US N 1 N N N Jazz Pharmaceuticals PLC 635400GAUMJCLEZRRV50 Jazz Pharmaceuticals plc N/A 9041.00000000 NS USD 1113399.15000000 1.214084079103 Long EC CORP US N 1 N N N 2025-01-30 Rydex Series Funds James Howley James Howley CFO XXXX