Vaxcyte, Inc.

NPORT-P false 0000899148 XXXXXXXX S000003802 C000010594 C000010597 C000010596 C000010595 Rydex Series Funds 811-07584 0000899148 5493004D62WV1EDNTU07 702 King Farm Blvd., Suite 200 Rockville 20850 301-296-5100 Biotechnology Fund S000003802 549300YENG103R306541 2025-03-31 2024-06-30 N 109491734.43 144379.05 109347355.38 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 N Vaxcyte Inc 254900M7NMHTGASX8D95 Vaxcyte, Inc. 92243G108 16322.00000000 NS USD 1232474.22000000 1.127118452674 Long EC CORP US N 1 N N N Krystal Biotech Inc 549300YONUY68210OE41 Krystal Biotech, Inc. 501147102 3945.00000000 NS USD 724459.80000000 0.662530700886 Long EC CORP US N 1 N N N Akero Therapeutics Inc 549300SI3KG74LBE2955 Akero Therapeutics, Inc. 00973Y108 25245.00000000 NS USD 592247.70000000 0.541620506451 Long EC CORP US N 1 N N N Biogen Inc W8J5WZB5IY3K0NDQT671 Biogen, Inc. 09062X103 12559.00000000 NS USD 2911427.38000000 2.662549423241 Long EC CORP US N 1 N N N Ionis Pharmaceuticals Inc 549300SI4ZGLG0BLUZ92 Ionis Pharmaceuticals, Inc. 462222100 28433.00000000 NS USD 1355116.78000000 1.239277141445 Long EC CORP US N 1 N N N Argenx SE 7245009C5FZE6G9ODQ71 Argenx SE 04016X101 3465.00000000 NS USD 1490088.60000000 1.362711146347 Long EC CORP NL N 1 N N N J.P. MORGAN SECURITIES LLC ZBUT11V806EZRVTWT807 J.P. Morgan Securities LLC N/A 459376.63000000 PA USD 459376.63000000 0.420107672840 Long RA CORP US N 2 Repurchase Y 5.32000000 2024-07-01 466265.64000000 USD 468564.22000000 USD UST N N N TG Therapeutics Inc 529900X21UKABN9NJ529 TG Therapeutics, Inc. 88322Q108 46215.00000000 NS USD 822164.85000000 0.751883616336 Long EC CORP US N 1 N N N Twist Bioscience Corp 549300T23BL59LCOH584 Twist Bioscience Corp. 90184D100 15458.00000000 NS USD 761770.24000000 0.696651727289 Long EC CORP US N 1 N N N Sarepta Therapeutics Inc 549300IKDPIED8J8IG21 Sarepta Therapeutics, Inc. 803607100 13412.00000000 NS USD 2119096.00000000 1.937949018186 Long EC CORP US N 1 N N N AstraZeneca PLC PY6ZZQWO2IZFZC3IOL08 AstraZeneca plc 046353108 36119.00000000 NS USD 2816920.81000000 2.576121571674 Long EC CORP GB N 1 N N N Gilead Sciences Inc 549300WTZWR07K8MNV44 Gilead Sciences, Inc. 375558103 70331.00000000 NS USD 4825409.91000000 4.412918715071 Long EC CORP US N 1 N N N Neurocrine Biosciences Inc 549300FECER0XBN49756 Neurocrine Biosciences, Inc. 64125C109 13507.00000000 NS USD 1859508.69000000 1.700552046766 Long EC CORP US N 1 N N N Illumina Inc SQ95QG8SR5Q56LSNF682 Illumina, Inc. 452327109 19243.00000000 NS USD 2008584.34000000 1.836884241982 Long EC CORP US N 1 N N N Viatris Inc 254900ZZTSW7NL773X71 Viatris, Inc. 92556V106 171258.00000000 NS USD 1820472.54000000 1.664852829474 Long EC CORP US N 1 N N N Vertex Pharmaceuticals Inc 54930015RAQRRZ5ZGJ91 Vertex Pharmaceuticals, Inc. 92532F100 9350.00000000 NS USD 4382532.00000000 4.007899399825 Long EC CORP US N 1 N N N REVOLUTION Medicines Inc 549300JU3X0LBCQ65892 REVOLUTION Medicines, Inc. 76155X100 31620.00000000 NS USD 1227172.20000000 1.122269665997 Long EC CORP US N 1 N N N BOFA SECURITIES, INC. 549300HN4UKV1E2R3U73 BofA Securities, Inc. N/A 362164.47000000 PA USD 362164.47000000 0.331205513605 Long RA CORP US N 2 Repurchase Y 5.30000000 2024-07-01 486633.28000000 USD 369407.76000000 USD UST N N N Medpace Holdings Inc 549300H8TYEUVTW14A54 Medpace Holdings, Inc. 58506Q109 3348.00000000 NS USD 1378873.80000000 1.261003336759 Long EC CORP US N 1 N N N Regeneron Pharmaceuticals Inc 549300RCBFWIRX3HYQ56 Regeneron Pharmaceuticals, Inc. 75886F107 4360.00000000 NS USD 4582490.80000000 4.190765093563 Long EC CORP US N 1 N N N Apellis Pharmaceuticals Inc 254900HS0ZFRXXSB9D42 Apellis Pharmaceuticals, Inc. 03753U106 23678.00000000 NS USD 908288.08000000 0.830644762137 Long EC CORP US N 1 N N N Beam Therapeutics Inc N/A Beam Therapeutics, Inc. 07373V105 26919.00000000 NS USD 630712.17000000 0.576796912744 Long EC CORP US N 1 N N N Pacific Biosciences of Califor 529900F1BWRE1M0KZN89 Pacific Biosciences of California, Inc. 69404D108 103284.00000000 NS USD 141499.08000000 0.129403294216 Long EC CORP US N 1 N N Recursion Pharmaceuticals Inc N/A Recursion Pharmaceuticals, Inc. 75629V104 74126.00000000 NS USD 555945.00000000 0.508421075267 Long EC CORP US N 1 N N N Legend Biotech Corp 254900EIUFZTW136H859 Legend Biotech Corp. 52490G102 33038.00000000 NS USD 1463253.02000000 1.338169556012 Long EC CORP KY N 1 N N N Alkermes PLC N/A Alkermes plc N/A 57132.00000000 NS USD 1376881.20000000 1.259181070465 Long EC CORP US N 1 N N N Ultragenyx Pharmaceutical Inc 529900EV44GVDN1DCX77 Ultragenyx Pharmaceutical, Inc. 90400D108 21535.00000000 NS USD 885088.50000000 0.809428355102 Long EC CORP US N 1 N N N BioNTech SE 894500UZJ5LG1F8J1U58 BioNTech SE 09075V102 11983.00000000 NS USD 962953.88000000 0.880637557857 Long EC CORP DE N 1 N N N Ironwood Pharmaceuticals Inc 549300PC8MR6QHH6P296 Ironwood Pharmaceuticals, Inc. 46333X108 76610.00000000 NS USD 499497.20000000 0.456798610505 Long EC CORP US N 1 N N N Royalty Pharma PLC 549300FGFN7VOK8BZR03 Royalty Pharma plc N/A 69616.00000000 NS USD 1835773.92000000 1.678846199453 Long EC CORP US N 1 N N N Amgen Inc 62QBXGPJ34PQ72Z12S66 Amgen, Inc. 031162100 21642.00000000 NS USD 6762042.90000000 6.184002234439 Long EC CORP US N 1 N N N SpringWorks Therapeutics Inc N/A SpringWorks Therapeutics, Inc. 85205L107 16194.00000000 NS USD 610027.98000000 0.557880872271 Long EC CORP US N 1 N N N Amicus Therapeutics Inc 549300MRD1SMUTNBPQ53 Amicus Therapeutics, Inc. 03152W109 83358.00000000 NS USD 826911.36000000 0.756224379754 Long EC CORP US N 1 N N N Cytokinetics Inc 549300BE5DY1HW7IHA64 Cytokinetics, Inc. 23282W605 23294.00000000 NS USD 1262068.92000000 1.154183304766 Long EC CORP US N 1 N N N Sage Therapeutics Inc 5493000JX4BJS9W6CN35 Sage Therapeutics, Inc. 78667J108 32164.00000000 NS USD 349301.04000000 0.319441690003 Long EC CORP US N 1 N N N Insmed Inc 529900Q55QAG41CCAC11 Insmed, Inc. 457669307 25565.00000000 NS USD 1712855.00000000 1.566434774803 Long EC CORP US N 1 N N N ACADIA Pharmaceuticals Inc 529900O3044NO0PEA039 ACADIA Pharmaceuticals, Inc. 004225108 45448.00000000 NS USD 738530.00000000 0.675398135998 Long EC CORP US N 1 N N N Moderna Inc 549300EI6OKH5K5Q2G38 Moderna, Inc. 60770K107 24446.00000000 NS USD 2902962.50000000 2.654808147770 Long EC CORP US N 1 N N N First American Funds N/A First American Government Obligations Fund - Class X N/A 155023.00000000 NS USD 155023.00000000 0.141771147058 Long STIV RF US N 1 N N Halozyme Therapeutics Inc 529900242I3SV9AGM753 Halozyme Therapeutics, Inc. 40637H109 25757.00000000 NS USD 1348636.52000000 1.233350834424 Long EC CORP US N 1 N N N Madrigal Pharmaceuticals Inc 549300CHIMT2EUSNJB60 Madrigal Pharmaceuticals, Inc. 558868105 2324.00000000 NS USD 651091.84000000 0.595434464544 Long EC CORP US N 1 N N N Exact Sciences Corp 549300VM3X1FYD4N9Z14 Exact Sciences Corp. 30063P105 33635.00000000 NS USD 1421078.75000000 1.299600475074 Long EC CORP US N 1 N N N Dynavax Technologies Corp 549300T5URIXWDILX594 Dynavax Technologies Corp. 268158201 52921.00000000 NS USD 594302.83000000 0.543499957483 Long EC CORP US N 1 N N N Immunovant Inc N/A Immunovant, Inc. 45258J102 25064.00000000 NS USD 661689.60000000 0.605126294733 Long EC CORP US N 1 N N N BioMarin Pharmaceutical Inc NSLL8ITTRR0J5HEMR848 BioMarin Pharmaceutical, Inc. 09061G101 24030.00000000 NS USD 1978389.90000000 1.809270917549 Long EC CORP US N 1 N N N Bridgebio Pharma Inc 54930028YG89VTY2J114 Bridgebio Pharma, Inc. 10806X102 34989.00000000 NS USD 886271.37000000 0.810510109659 Long EC CORP US N 1 N N N Intellia Therapeutics Inc 5493002T5BCPE5DZC723 Intellia Therapeutics, Inc. 45826J105 29606.00000000 NS USD 662582.28000000 0.605942665643 Long EC CORP US N 1 N N N Viking Therapeutics Inc 529900IVC72YPFA25M37 Viking Therapeutics, Inc. 92686J106 22516.00000000 NS USD 1193573.16000000 1.091542777465 Long EC CORP US N 1 N N N Intra-Cellular Therapies Inc 5299002U2KGF193IJA20 Intra-Cellular Therapies, Inc. 46116X101 19307.00000000 NS USD 1322336.43000000 1.209298958721 Long EC CORP US N 1 N N N Roivant Sciences Ltd. N/A Roivant Sciences Ltd. N/A 107377.00000000 NS USD 1134974.89000000 1.037953671632 Long EC CORP US N 1 N N N Arrowhead Pharmaceuticals Inc 549300O3CSB8T7OZ3D66 Arrowhead Pharmaceuticals, Inc. 04280A100 34574.00000000 NS USD 898578.26000000 0.821764968048 Long EC CORP US N 1 N N N AbbVie Inc FR5LCKFTG8054YNNRU85 AbbVie, Inc. 00287Y109 52186.00000000 NS USD 8950942.72000000 8.185788022850 Long EC CORP US N 1 N N N Blueprint Medicines Corp 5299004CC60O9T5HVM83 Blueprint Medicines Corp. 09627Y109 9286.00000000 NS USD 1000845.08000000 0.915289699071 Long EC CORP US N 1 N N N Exelixis Inc 254900PJQB59O2O95R37 Exelixis, Inc. 30161Q104 57665.00000000 NS USD 1295732.55000000 1.184969261942 Long EC CORP US N 1 N N N Iovance Biotherapeutics Inc 2549002L8WT2ACU5Q878 Iovance Biotherapeutics, Inc. 462260100 89606.00000000 NS USD 718640.12000000 0.657208505411 Long EC CORP US N 1 N N N Crinetics Pharmaceuticals Inc 549300Q1CNFXK5P31D28 Crinetics Pharmaceuticals, Inc. 22663K107 20096.00000000 NS USD 900099.84000000 0.823156478610 Long EC CORP US N 1 N N N Natera Inc N/A Natera, Inc. 632307104 16365.00000000 NS USD 1772165.85000000 1.620675547059 Long EC CORP US N 1 N N N PTC Therapeutics Inc 549300UJLWOIWFDGB318 PTC Therapeutics, Inc. 69366J200 21151.00000000 NS USD 646797.58000000 0.591507291376 Long EC CORP US N 1 N N N Guardant Health Inc 254900M8C3E5VC8BR186 Guardant Health, Inc. 40131M109 31279.00000000 NS USD 903337.52000000 0.826117391555 Long EC CORP US N 1 N N N GRAIL Inc 2549009XSNESW3VE8024 GRAIL, Inc. 384747101 3198.83340000 NS USD 49166.07000000 0.044963199913 Long EC CORP US N 1 N N Incyte Corp 549300Z4WN6JVZ3T4680 Incyte Corp. 45337C102 27942.00000000 NS USD 1693844.04000000 1.549048931374 Long EC CORP US N 1 N N N Corteva Inc 549300WZN9I2QKLS0O94 Corteva, Inc. 22052L104 58795.00000000 NS USD 3171402.30000000 2.900300870541 Long EC CORP US N 1 N N N Alnylam Pharmaceuticals Inc 529900S3ZI14OWRJII50 Alnylam Pharmaceuticals, Inc. 02043Q107 14179.00000000 NS USD 3445497.00000000 3.150965094698 Long EC CORP US N 1 N N N Nuvalent Inc N/A Nuvalent, Inc. 670703107 8070.00000000 NS USD 612190.20000000 0.559858258914 Long EC CORP US N 1 N N N United Therapeutics Corp 5299005C4HZL4UWROC14 United Therapeutics Corp. 91307C102 6215.00000000 NS USD 1979788.25000000 1.810549732199 Long EC CORP US N 1 N N N Axsome Therapeutics Inc 549300EXGR0XLRJEIB95 Axsome Therapeutics, Inc. 05464T104 11908.00000000 NS USD 958594.00000000 0.876650374093 Long EC CORP US N 1 N N N Ardelyx Inc 549300F542QR4SXHCY32 Ardelyx, Inc. 039697107 95395.00000000 NS USD 706876.95000000 0.646450888129 Long EC CORP US N 1 N N N Prothena Corp PLC 5299009ZXQ8NIIJ8OL30 Prothena Corporation plc N/A 38699.00000000 NS USD 798747.36000000 0.730467926932 Long EC CORP US N 1 N N N Novavax Inc 529900J4GJHPEPQ23205 Novavax, Inc. 670002401 48422.00000000 NS USD 613022.52000000 0.560619429587 Long EC CORP US N 1 N N N CRISPR Therapeutics AG 506700O6IRRIQLT3W370 CRISPR Therapeutics AG N/A 20853.00000000 NS USD 1126270.53000000 1.029993387664 Long EC CORP US N 1 N N N Cerevel Therapeutics Holdings 254900RJNIRS9COSQR41 Cerevel Therapeutics Holdings, Inc. 15678U128 21727.00000000 NS USD 888417.03000000 0.812472351903 Long EC CORP US N 1 N N N Jazz Pharmaceuticals PLC 635400GAUMJCLEZRRV50 Jazz Pharmaceuticals plc N/A 11663.00000000 NS USD 1244791.99000000 1.138383261007 Long EC CORP US N 1 N N N 2024-07-30 Rydex Series Funds James Howley James Howley CFO XXXX