<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.sec.gov/edgar/nport eis_NPORT_Filer.xsd">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0000899148</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000003802</seriesId>
        <classId>C000010594</classId>
        <classId>C000010597</classId>
        <classId>C000010596</classId>
        <classId>C000010595</classId>
      </seriesClassInfo>

    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>Rydex Series Funds</regName>
      <regFileNumber>811-07584</regFileNumber>
      <regCik>0000899148</regCik>
      <regLei>5493004D62WV1EDNTU07</regLei>
      <regStreet1>702 King Farm Blvd., Suite 200</regStreet1>
      <regCity>Rockville</regCity>
      <regStateConditional regCountry="US" regState="US-MD"/>
      <regZipOrPostalCode>20850</regZipOrPostalCode>
      <regPhone>301-296-5100</regPhone>
      <seriesName>Biotechnology Fund</seriesName>
      <seriesId>S000003802</seriesId>
      <seriesLei>549300YENG103R306541</seriesLei>
      <repPdEnd>2021-03-31</repPdEnd>
      <repPdDate>2020-06-30</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>240214247.66</totAssets>
      <totLiabs>512466.81</totLiabs>
      <netAssets>239701780.85</netAssets>
      <assetsAttrMiscSec>0.00000000</assetsAttrMiscSec>
      <assetsInvested>0.00000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.00000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.00000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.00000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.00000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.00000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.00000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.00000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.00000000</amtPayAftOneYrOther>
      <delayDeliv>0.00000000</delayDeliv>
      <standByCommit>0.00000000</standByCommit>
      <liquidPref>0.00000000</liquidPref>
      <cshNotRptdInCorD>0.00000000</cshNotRptdInCorD>
      <borrowers>
        <borrower aggrVal="2125457.24000000" lei="9R7GPTSO7KV3UQJZQ078" name="MORGAN STANLEY &amp; CO LLC"/>
        <borrower aggrVal="90822.20000000" lei="AC28XWWI3WIBK2824319" name="BARCLAYS CAPITAL, INC."/>
        <borrower aggrVal="294165.50000000" lei="58PU97L1C0WSRCWADL48" name="JEFFERIES &amp; COMPANY INC"/>
        <borrower aggrVal="897372.55000000" lei="FOR8UP27PHTHYVLBNG30" name="GOLDMAN, SACHS &amp; CO"/>
      </borrowers>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000010596" rtn1="15.95830000" rtn2="8.96619100" rtn3="1.46319600"/>
          <monthlyTotReturn classId="C000010595" rtn1="15.94923000" rtn2="8.96869400" rtn3="1.46447700"/>
          <monthlyTotReturn classId="C000010597" rtn1="15.88180700" rtn2="8.90005700" rtn3="1.40449400"/>
          <monthlyTotReturn classId="C000010594" rtn1="15.97870500" rtn2="8.98033600" rtn3="1.48888000"/>
        </monthlyTotReturns>
        <othMon1 netRealizedGain="2942337.44000000" netUnrealizedAppr="28368023.08000000"/>
        <othMon2 netRealizedGain="-255882.10000000" netUnrealizedAppr="24185572.06000000"/>
        <othMon3 netRealizedGain="4540673.28000000" netUnrealizedAppr="-1543651.83000000"/>
      </returnInfo>
      <mon1Flow redemption="20420625.68000000" reinvestment="0.00000000" sales="95804046.91000000"/>
      <mon2Flow redemption="12054726.45000000" reinvestment="0.00000000" sales="18011574.78000000"/>
      <mon3Flow redemption="65623449.88000000" reinvestment="0.00000000" sales="13250982.27000000"/>


    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>PRA Health Sciences Inc</name>
        <lei>549300R1HR1VWWHIAK47</lei>
        <title>PRA Health Sciences, Inc.</title>
        <cusip>69354M108</cusip>
        <identifiers>
          <isin value="US69354M1080"/>
        </identifiers>
        <balance>33491.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3258339.39000000</valUSD>
        <pctVal>1.359330489095</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Myriad Genetics Inc</name>
        <lei>52990044IHUOUMETT163</lei>
        <title>Myriad Genetics, Inc.</title>
        <cusip>62855J104</cusip>
        <identifiers>
          <isin value="US62855J1043"/>
        </identifiers>
        <balance>97323.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1103642.82000000</valUSD>
        <pctVal>0.460423287672</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BARCLAYS CAPITAL INC.</name>
        <lei>AC28XWWI3WIBK2824319</lei>
        <title>Barclays Capital, Inc.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="REPO-BARC"/>
        </identifiers>
        <balance>333324.64000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>333324.64000000</valUSD>
        <pctVal>0.139058057398</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>RA</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <repurchaseAgrmt>
          <transCat>Repurchase</transCat>
          <notClearedCentCparty isCleared="N">
            <counterpartyInfos>
              <counterpartyInfo lei="AC28XWWI3WIBK2824319" name="BARCLAYS CAPITAL INC."/>
            </counterpartyInfos>
          </notClearedCentCparty>
          <isTriParty>Y</isTriParty>
          <repurchaseRt>0.07000000</repurchaseRt>
          <maturityDt>2020-07-01</maturityDt>
          <repurchaseCollaterals>
            <repurchaseCollateral>
              <principalAmt>321580.05000000</principalAmt>
              <principalCd>USD</principalCd>
              <collateralVal>339991.64000000</collateralVal>
              <collateralCd>USD</collateralCd>
              <invstCat>UST</invstCat>
            </repurchaseCollateral>
          </repurchaseCollaterals>
        </repurchaseAgrmt>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Guardant Health Inc</name>
        <lei>N/A</lei>
        <title>Guardant Health, Inc.</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
        </identifiers>
        <balance>46098.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3739930.74000000</valUSD>
        <pctVal>1.560243201672</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics Inc</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>Sarepta Therapeutics, Inc.</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
        </identifiers>
        <balance>28479.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4566322.86000000</valUSD>
        <pctVal>1.905001641542</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>Regeneron Pharmaceuticals, Inc.</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
        </identifiers>
        <balance>17336.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10811596.40000000</valUSD>
        <pctVal>4.510436410468</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BOFA SECURITIES, INC.</name>
        <lei>549300HN4UKV1E2R3U73</lei>
        <title>BofA Securities, Inc.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="REPO-BANK"/>
        </identifiers>
        <balance>354600.68000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>354600.68000000</valUSD>
        <pctVal>0.147934103260</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>RA</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <repurchaseAgrmt>
          <transCat>Repurchase</transCat>
          <notClearedCentCparty isCleared="N">
            <counterpartyInfos>
              <counterpartyInfo lei="549300HN4UKV1E2R3U73" name="BOFA SECURITIES, INC."/>
            </counterpartyInfos>
          </notClearedCentCparty>
          <isTriParty>Y</isTriParty>
          <repurchaseRt>0.07000000</repurchaseRt>
          <maturityDt>2020-07-01</maturityDt>
          <repurchaseCollaterals>
            <repurchaseCollateral>
              <principalAmt>447700.88000000</principalAmt>
              <principalCd>USD</principalCd>
              <collateralVal>361692.69000000</collateralVal>
              <collateralCd>USD</collateralCd>
              <invstCat>UST</invstCat>
            </repurchaseCollateral>
          </repurchaseCollaterals>
        </repurchaseAgrmt>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Horizon Therapeutics Plc</name>
        <lei>529900P0GSQ79OOZEV53</lei>
        <title>Horizon Therapeutics plc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00BQPVQZ61"/>
        </identifiers>
        <balance>82490.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4584794.20000000</valUSD>
        <pctVal>1.912707608488</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>Alnylam Pharmaceuticals, Inc.</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
        </identifiers>
        <balance>36760.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5444523.60000000</valUSD>
        <pctVal>2.271373863261</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACADIA Pharmaceuticals Inc</name>
        <lei>529900O3044NO0PEA039</lei>
        <title>ACADIA Pharmaceuticals, Inc.</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
        </identifiers>
        <balance>72428.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3510585.16000000</valUSD>
        <pctVal>1.464563653866</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FibroGen Inc</name>
        <lei>549300Q914ULWWY95822</lei>
        <title>FibroGen, Inc.</title>
        <cusip>31572Q808</cusip>
        <identifiers>
          <isin value="US31572Q8087"/>
        </identifiers>
        <balance>62477.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2532192.81000000</valUSD>
        <pctVal>1.056392990081</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Iovance Biotherapeutics Inc</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>Iovance Biotherapeutics, Inc.</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
        </identifiers>
        <balance>91690.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2516890.50000000</valUSD>
        <pctVal>1.050009095082</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acceleron Pharma Inc</name>
        <lei>529900TQRID2UY164805</lei>
        <title>Acceleron Pharma, Inc.</title>
        <cusip>00434H108</cusip>
        <identifiers>
          <isin value="US00434H1086"/>
        </identifiers>
        <balance>30440.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2900018.80000000</valUSD>
        <pctVal>1.209844494987</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>Ultragenyx Pharmaceutical, Inc.</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
        </identifiers>
        <balance>37580.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2939507.60000000</valUSD>
        <pctVal>1.226318632083</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>United Therapeutics Corp</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>United Therapeutics Corp.</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
        </identifiers>
        <balance>25948.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3139708.00000000</valUSD>
        <pctVal>1.309839246444</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amgen Inc</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>Amgen, Inc.</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
        </identifiers>
        <balance>65966.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15558740.76000000</valUSD>
        <pctVal>6.490874078960</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Intercept Pharmaceuticals, Inc.</title>
        <cusip>45845P108</cusip>
        <identifiers>
          <isin value="US45845P1084"/>
        </identifiers>
        <balance>27643.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1324376.13000000</valUSD>
        <pctVal>0.552509925167</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bluebird Bio Inc</name>
        <lei>N/A</lei>
        <title>Bluebird Bio, Inc.</title>
        <cusip>09609G100</cusip>
        <identifiers>
          <isin value="US09609G1004"/>
        </identifiers>
        <balance>42451.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2591209.04000000</valUSD>
        <pctVal>1.081013679085</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals Inc</name>
        <lei>529900ONJHY8EOGYT555</lei>
        <title>Agios Pharmaceuticals, Inc.</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
        </identifiers>
        <balance>49938.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2670684.24000000</valUSD>
        <pctVal>1.114169544560</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>First American Funds</name>
        <lei>N/A</lei>
        <title>First American Government Obligations Fund</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="FGZXX"/>
        </identifiers>
        <balance>3474236.50000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3474236.50000000</valUSD>
        <pctVal>1.449399536240</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="3474236.50000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Corteva Inc</name>
        <lei>549300WZN9I2QKLS0O94</lei>
        <title>Corteva, Inc.</title>
        <cusip>22052L104</cusip>
        <identifiers>
          <isin value="US22052L1044"/>
        </identifiers>
        <balance>224718.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6020195.22000000</valUSD>
        <pctVal>2.511535458206</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illumina Inc</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>Illumina, Inc.</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
        </identifiers>
        <balance>26443.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9793165.05000000</valUSD>
        <pctVal>4.085562074371</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Seattle Genetics Inc</name>
        <lei>N/A</lei>
        <title>Seattle Genetics, Inc.</title>
        <cusip>812578102</cusip>
        <identifiers>
          <isin value="US8125781026"/>
        </identifiers>
        <balance>43125.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7327800.00000000</valUSD>
        <pctVal>3.057048626845</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Jazz Pharmaceuticals PLC</name>
        <lei>635400GAUMJCLEZRRV50</lei>
        <title>Jazz Pharmaceuticals plc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B4Q5ZN47"/>
        </identifiers>
        <balance>30697.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3387106.98000000</valUSD>
        <pctVal>1.413050402875</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BeiGene Ltd</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BeiGene Ltd.</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
        </identifiers>
        <balance>14880.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2803392.00000000</valUSD>
        <pctVal>1.169533238367</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exact Sciences Corp</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
        <title>Exact Sciences Corp.</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
        </identifiers>
        <balance>55347.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4811868.18000000</valUSD>
        <pctVal>2.007439478729</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Moderna Inc</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>Moderna, Inc.</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
        </identifiers>
        <balance>100670.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6464020.70000000</valUSD>
        <pctVal>2.696692814328</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Portola Pharmaceuticals Inc</name>
        <lei>549300BM3O4O0CNBGJ64</lei>
        <title>Portola Pharmaceuticals, Inc.</title>
        <cusip>737010108</cusip>
        <identifiers>
          <isin value="US7370101088"/>
        </identifiers>
        <balance>87170.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1568188.30000000</valUSD>
        <pctVal>0.654224718080</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Incyte Corp</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>Incyte Corp.</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
        </identifiers>
        <balance>61920.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6437822.40000000</valUSD>
        <pctVal>2.685763275170</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes PLC</name>
        <lei>N/A</lei>
        <title>Alkermes plc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
        </identifiers>
        <balance>156156.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3030207.18000000</valUSD>
        <pctVal>1.264157141117</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arrowhead Pharmaceuticals Inc</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>Arrowhead Pharmaceuticals, Inc.</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
        </identifiers>
        <balance>68237.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2947156.03000000</valUSD>
        <pctVal>1.229509442753</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirati Therapeutics Inc</name>
        <lei>529900GYRW59IDQV6N54</lei>
        <title>Mirati Therapeutics, Inc.</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
        </identifiers>
        <balance>25953.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2963054.01000000</valUSD>
        <pctVal>1.236141842372</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>J.P. MORGAN SECURITIES LLC</name>
        <lei>ZBUT11V806EZRVTWT807</lei>
        <title>J.P. Morgan Securities LLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="REPO-JP M"/>
        </identifiers>
        <balance>856222.94000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>856222.94000000</valUSD>
        <pctVal>0.357203412074</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>RA</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <repurchaseAgrmt>
          <transCat>Repurchase</transCat>
          <notClearedCentCparty isCleared="N">
            <counterpartyInfos>
              <counterpartyInfo lei="ZBUT11V806EZRVTWT807" name="J.P. MORGAN SECURITIES LLC"/>
            </counterpartyInfos>
          </notClearedCentCparty>
          <isTriParty>Y</isTriParty>
          <repurchaseRt>0.07000000</repurchaseRt>
          <maturityDt>2020-07-01</maturityDt>
          <repurchaseCollaterals>
            <repurchaseCollateral>
              <principalAmt>766646.51000000</principalAmt>
              <principalCd>USD</principalCd>
              <collateralVal>873350.80000000</collateralVal>
              <collateralCd>USD</collateralCd>
              <invstCat>UST</invstCat>
            </repurchaseCollateral>
          </repurchaseCollaterals>
        </repurchaseAgrmt>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Syneos Health Inc</name>
        <lei>549300F1ZGKDS8P6GU13</lei>
        <title>Syneos Health, Inc.</title>
        <cusip>87166B102</cusip>
        <identifiers>
          <isin value="US87166B1026"/>
        </identifiers>
        <balance>57610.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3355782.50000000</valUSD>
        <pctVal>1.399982298045</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exelixis Inc</name>
        <lei>N/A</lei>
        <title>Exelixis, Inc.</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
        </identifiers>
        <balance>154006.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3656102.44000000</valUSD>
        <pctVal>1.525271287945</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Global Blood Therapeutics Inc</name>
        <lei>549300U4G0QKK99GRT15</lei>
        <title>Global Blood Therapeutics, Inc.</title>
        <cusip>37890U108</cusip>
        <identifiers>
          <isin value="US37890U1088"/>
        </identifiers>
        <balance>40813.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2576524.69000000</valUSD>
        <pctVal>1.074887587761</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mylan NV</name>
        <lei>549300A0CD4KNFGIIS89</lei>
        <title>Mylan N.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0011031208"/>
        </identifiers>
        <balance>239727.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3854810.16000000</valUSD>
        <pctVal>1.608169178522</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biogen Inc</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>Biogen, Inc.</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
        </identifiers>
        <balance>34304.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9178035.20000000</valUSD>
        <pctVal>3.828939095677</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences, Inc.</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>171221.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13173743.74000000</valUSD>
        <pctVal>5.495888972240</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amarin Corp PLC</name>
        <lei>5493009JFIGUFEVPK217</lei>
        <title>Amarin Corporation plc</title>
        <cusip>023111206</cusip>
        <identifiers>
          <isin value="US0231112063"/>
        </identifiers>
        <balance>432103.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2990152.76000000</valUSD>
        <pctVal>1.247447035811</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2125457.24000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ligand Pharmaceuticals Inc</name>
        <lei>5493008K7TB0IKP37H79</lei>
        <title>Ligand Pharmaceuticals, Inc.</title>
        <cusip>53220K504</cusip>
        <identifiers>
          <isin value="US53220K5048"/>
        </identifiers>
        <balance>16101.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1800896.85000000</valUSD>
        <pctVal>0.751307246702</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1282360.25000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunomedics Inc</name>
        <lei>5493007ZU7DDO8PSIM59</lei>
        <title>Immunomedics, Inc.</title>
        <cusip>452907108</cusip>
        <identifiers>
          <isin value="US4529071080"/>
        </identifiers>
        <balance>108622.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3849563.68000000</valUSD>
        <pctVal>1.605980425489</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurocrine Biosciences Inc</name>
        <lei>549300FECER0XBN49756</lei>
        <title>Neurocrine Biosciences, Inc.</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
        </identifiers>
        <balance>36249.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4422378.00000000</valUSD>
        <pctVal>1.844949997583</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alexion Pharmaceuticals Inc</name>
        <lei>M1YXUUZR0EIMU8T0EM75</lei>
        <title>Alexion Pharmaceuticals, Inc.</title>
        <cusip>015351109</cusip>
        <identifiers>
          <isin value="US0153511094"/>
        </identifiers>
        <balance>57241.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6424729.84000000</valUSD>
        <pctVal>2.680301254841</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Inc</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>Vertex Pharmaceuticals, Inc.</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
        </identifiers>
        <balance>40228.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11678590.68000000</valUSD>
        <pctVal>4.872133464585</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>Ionis Pharmaceuticals, Inc.</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
        </identifiers>
        <balance>64192.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3784760.32000000</valUSD>
        <pctVal>1.578945432353</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC Therapeutics Inc</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC Therapeutics, Inc.</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
        </identifiers>
        <balance>46870.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2378183.80000000</valUSD>
        <pctVal>0.992142733177</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BioMarin Pharmaceutical, Inc.</title>
        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
        </identifiers>
        <balance>51946.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6407019.64000000</valUSD>
        <pctVal>2.672912824126</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bio-Techne Corp</name>
        <lei>54930073RLKQ51TILZ35</lei>
        <title>Bio-Techne Corp.</title>
        <cusip>09073M104</cusip>
        <identifiers>
          <isin value="US09073M1045"/>
        </identifiers>
        <balance>16218.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4282687.26000000</valUSD>
        <pctVal>1.786673108899</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novocure Ltd</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>Novocure Ltd.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
        </identifiers>
        <balance>51830.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3073519.00000000</valUSD>
        <pctVal>1.282226185012</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Clinical Data Inc</name>
        <lei>N/A</lei>
        <title>Clinical Data, Inc.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="CLDA_R"/>
        </identifiers>
        <balance>24000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.02000000</valUSD>
        <pctVal>0.000000008343</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Rights"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AbbVie Inc</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>AbbVie, Inc.</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
        </identifiers>
        <balance>177919.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17468087.42000000</valUSD>
        <pctVal>7.287424965328</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics Inc</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>Sage Therapeutics, Inc.</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
        </identifiers>
        <balance>20116.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>836423.28000000</valUSD>
        <pctVal>0.348943289880</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nektar Therapeutics</name>
        <lei>5299005I24806IOIYE03</lei>
        <title>Nektar Therapeutics</title>
        <cusip>640268108</cusip>
        <identifiers>
          <isin value="US6402681083"/>
        </identifiers>
        <balance>117891.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2730355.56000000</valUSD>
        <pctVal>1.139063527320</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2020-07-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Rydex Series Funds</ncom:nameOfApplicant>
      <ncom:signature>John Sullivan</ncom:signature>
      <ncom:signerName>John Sullivan</ncom:signerName>
      <ncom:title>CFO</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
