Vaxcyte, Inc.

NPORT-P false 0000899148 XXXXXXXX S000003802 C000010594 C000010597 C000010596 C000010595 Rydex Series Funds 811-07584 0000899148 5493004D62WV1EDNTU07 702 King Farm Blvd., Suite 200 Rockville 20850 301-296-5100 Biotechnology Fund S000003802 549300YENG103R306541 2026-03-31 2025-12-31 N 109233138.42 230051.60 109003086.82 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 1092781.62000000 N Vaxcyte Inc 254900M7NMHTGASX8D95 Vaxcyte, Inc. 92243G108 23633.00000000 NS USD 1090426.62000000 1.000363064764 Long EC CORP US N 1 N N N Krystal Biotech Inc 549300YONUY68210OE41 Krystal Biotech, Inc. 501147102 2380.00000000 NS USD 586765.20000000 0.538301452846 Long EC CORP US N 1 N N N Biogen Inc W8J5WZB5IY3K0NDQT671 Biogen, Inc. 09062X103 12936.00000000 NS USD 2276606.64000000 2.088570797778 Long EC CORP US N 1 N N N Sanofi SA N/A Sanofi SA N/A 8866.00000000 NS USD 0.01000000 0.000000009174 Long CORP FR N 1 N N N Veracyte Inc 529900ESWZRHXOW27Z37 Veracyte, Inc. 92337F107 19321.00000000 NS USD 813414.10000000 0.746230335057 Long EC CORP US N 1 N N N Ionis Pharmaceuticals Inc 549300SI4ZGLG0BLUZ92 Ionis Pharmaceuticals, Inc. 462222100 19693.00000000 NS USD 1557913.23000000 1.429237717435 Long EC CORP US N 1 N N N Argenx SE 7245009C5FZE6G9ODQ71 Argenx SE 04016X101 1845.00000000 NS USD 1551552.75000000 1.423402579930 Long EC CORP NL N 1 N N N Summit Therapeutics Inc N/A Summit Therapeutics, Inc. 86627T108 33632.00000000 NS USD 588223.68000000 0.539639470000 Long EC CORP US N 1 N N N J.P. MORGAN SECURITIES LLC ZBUT11V806EZRVTWT807 J.P. Morgan Securities LLC N/A 117823.21000000 PA USD 117823.21000000 0.108091626978 Long RA CORP US N 2 Repurchase Y 3.82000000 2026-01-02 117308.53000000 USD 120179.77000000 USD UST N N N TG Therapeutics Inc 529900X21UKABN9NJ529 TG Therapeutics, Inc. 88322Q108 29921.00000000 NS USD 891945.01000000 0.818275001214 Long EC CORP US N 1 N N N Arcellx Inc N/A Arcellx, Inc. 03940C100 7434.00000000 NS USD 484696.80000000 0.444663370680 Long EC CORP US N 1 N N N Twist Bioscience Corp 549300T23BL59LCOH584 Twist Bioscience Corp. 90184D100 19190.00000000 NS USD 608706.80000000 0.558430791051 Long EC CORP US N 1 N N N Sarepta Therapeutics Inc 549300IKDPIED8J8IG21 Sarepta Therapeutics, Inc. 803607100 30630.00000000 NS USD 659157.60000000 0.604714617934 Long EC CORP US N 1 N N N AstraZeneca PLC PY6ZZQWO2IZFZC3IOL08 AstraZeneca plc 046353108 26373.00000000 NS USD 2424469.89000000 2.224221314029 Long EC CORP GB N 1 N N N Gilead Sciences Inc 549300WTZWR07K8MNV44 Gilead Sciences, Inc. 375558103 39844.00000000 NS USD 4890452.56000000 4.486526668805 Long EC CORP US N 1 N N N Neurocrine Biosciences Inc 549300FECER0XBN49756 Neurocrine Biosciences, Inc. 64125C109 11298.00000000 NS USD 1602395.34000000 1.470045837001 Long EC CORP US N 1 N N N Illumina Inc SQ95QG8SR5Q56LSNF682 Illumina, Inc. 452327109 14715.00000000 NS USD 1930019.40000000 1.770609857303 Long EC CORP US N 1 N N N Viatris Inc 254900ZZTSW7NL773X71 Viatris, Inc. 92556V106 140709.00000000 NS USD 1751827.05000000 1.607135266630 Long EC CORP US N 1 N N N Vertex Pharmaceuticals Inc 54930015RAQRRZ5ZGJ91 Vertex Pharmaceuticals, Inc. 92532F100 10599.00000000 NS USD 4805162.64000000 4.408281251644 Long EC CORP US N 1 N N N Kymera Therapeutics Inc N/A Kymera Therapeutics, Inc. 501575104 8853.00000000 NS USD 688851.93000000 0.631956351050 Long EC CORP US N 1 N N N Revolution Medicines Inc 549300JU3X0LBCQ65892 Revolution Medicines, Inc. 76155X100 21352.00000000 NS USD 1700686.80000000 1.560218934724 Long EC CORP US N 1 N N N Protagonist Therapeutics Inc N/A Protagonist Therapeutics, Inc. 74366E102 11396.00000000 NS USD 995326.64000000 0.913117847427 Long EC CORP US N 1 N N N BOFA SECURITIES, INC. 549300HN4UKV1E2R3U73 BofA Securities, Inc. N/A 117823.22000000 PA USD 117823.22000000 0.108091636152 Long RA CORP US N 2 Repurchase Y 3.81000000 2026-01-02 112716.01000000 USD 120179.71000000 USD UST N N N Medpace Holdings Inc 549300H8TYEUVTW14A54 Medpace Holdings, Inc. 58506Q109 2281.00000000 NS USD 1281123.65000000 1.175309514046 Long EC CORP US N 1 N N N Regeneron Pharmaceuticals Inc 549300RCBFWIRX3HYQ56 Regeneron Pharmaceuticals, Inc. 75886F107 5152.00000000 NS USD 3976674.24000000 3.648221675196 Long EC CORP US N 1 N N N Apellis Pharmaceuticals Inc 254900HS0ZFRXXSB9D42 Apellis Pharmaceuticals, Inc. 03753U106 29157.00000000 NS USD 732423.84000000 0.671929448392 Long EC CORP US N 1 N N N Beam Therapeutics Inc N/A Beam Therapeutics, Inc. 07373V105 25336.00000000 NS USD 702313.92000000 0.644306450843 Long EC CORP US N 1 N N N Recursion Pharmaceuticals Inc N/A Recursion Pharmaceuticals, Inc. 75629V104 149289.00000000 NS USD 610592.01000000 0.560160292532 Long EC CORP US N 1 N N N Ascendis Pharma A/S 549300B66JN3W3J8GH73 Ascendis Pharma A/S 04351P101 3657.00000000 NS USD 779818.68000000 0.715409721641 Long EC CORP DK N 1 N N N Legend Biotech Corp 254900EIUFZTW136H859 Legend Biotech Corp. 52490G102 39822.00000000 NS USD 865730.28000000 0.794225471274 Long EC CORP KY N 1 N N N Alkermes PLC N/A Alkermes plc N/A 43315.00000000 NS USD 1211953.70000000 1.111852641385 Long EC CORP US N 1 N N N ADMA Biologics Inc N/A ADMA Biologics, Inc. 000899104 47114.00000000 NS USD 859359.36000000 0.788380756059 Long EC CORP US N 1 N N N Ultragenyx Pharmaceutical Inc 529900EV44GVDN1DCX77 Ultragenyx Pharmaceutical, Inc. 90400D108 22214.00000000 NS USD 510922.00000000 0.468722505853 Long EC CORP US N 1 N N N BioNTech SE 894500UZJ5LG1F8J1U58 BioNTech SE 09075V102 12684.00000000 NS USD 1207516.80000000 1.107782206199 Long EC CORP DE N 1 N N N Liquidia Corp 549300O826O5VQJTG707 Liquidia Corp. 53635D202 19725.00000000 NS USD 680315.25000000 0.624124756323 Long EC CORP US N 1 N N N Royalty Pharma PLC 549300FGFN7VOK8BZR03 Royalty Pharma plc N/A 51524.00000000 NS USD 1990887.36000000 1.826450441066 Long EC CORP US N 1 N N N Amgen Inc 62QBXGPJ34PQ72Z12S66 Amgen, Inc. 031162100 16516.00000000 NS USD 5405851.96000000 4.959356764755 Long EC CORP US N 1 N N N Amicus Therapeutics Inc 549300MRD1SMUTNBPQ53 Amicus Therapeutics, Inc. 03152W109 78127.00000000 NS USD 1112528.48000000 1.020639426328 Long EC CORP US N 1 N N N Rhythm Pharmaceuticals Inc 529900JPNWXQ8DPLA551 Rhythm Pharmaceuticals, Inc. 76243J105 8285.00000000 NS USD 886826.40000000 0.813579161720 Long EC CORP US N 1 N N N Cytokinetics Inc 549300BE5DY1HW7IHA64 Cytokinetics, Inc. 23282W605 20111.00000000 NS USD 1277852.94000000 1.172308947644 Long EC CORP US N 1 N N N Insmed Inc 529900Q55QAG41CCAC11 Insmed, Inc. 457669307 14529.00000000 NS USD 2528627.16000000 2.319775736420 Long EC CORP US N 1 N N N BeOne Medicines Ltd 549300JFUK6FRD5MH739 BeOne Medicines Ltd. 07725L102 7379.00000000 NS USD 2241813.99000000 2.056651839320 Long EC CORP CH N 1 N N N ACADIA Pharmaceuticals Inc 529900O3044NO0PEA039 ACADIA Pharmaceuticals, Inc. 004225108 30598.00000000 NS USD 817272.58000000 0.749770124720 Long EC CORP US N 1 N N N Moderna Inc 549300EI6OKH5K5Q2G38 Moderna, Inc. 60770K107 48915.00000000 NS USD 1442503.35000000 1.323360091977 Long EC CORP US N 1 N N N Halozyme Therapeutics Inc 529900242I3SV9AGM753 Halozyme Therapeutics, Inc. 40637H109 19343.00000000 NS USD 1301783.90000000 1.194263335083 Long EC CORP US N 1 N N N Madrigal Pharmaceuticals Inc 549300CHIMT2EUSNJB60 Madrigal Pharmaceuticals, Inc. 558868105 1637.00000000 NS USD 953290.58000000 0.874553746880 Long EC CORP US N 1 N N N Exact Sciences Corp 549300VM3X1FYD4N9Z14 Exact Sciences Corp. 30063P105 18983.00000000 NS USD 1927913.48000000 1.768677875318 Long EC CORP US N 1 N N N BioMarin Pharmaceutical Inc NSLL8ITTRR0J5HEMR848 BioMarin Pharmaceutical, Inc. 09061G101 26548.00000000 NS USD 1577747.64000000 1.447433908551 Long EC CORP US N 1 N N N Bridgebio Pharma Inc 54930028YG89VTY2J114 Bridgebio Pharma, Inc. 10806X102 21199.00000000 NS USD 1621511.51000000 1.487583110997 Long EC CORP US N 1 N N N Celcuity Inc 25490070W7UU7W2SEY87 Celcuity, Inc. 15102K100 6702.00000000 NS USD 668457.48000000 0.613246376319 Long EC CORP US N 1 N N N Intellia Therapeutics Inc 5493002T5BCPE5DZC723 Intellia Therapeutics, Inc. 45826J105 48347.00000000 NS USD 434639.53000000 0.398740570271 Long EC CORP US N 1 N N N Viking Therapeutics Inc 529900IVC72YPFA25M37 Viking Therapeutics, Inc. 92686J106 23939.00000000 NS USD 842174.02000000 0.772614835569 Long EC CORP US N 1 N N N Avidity Biosciences Inc N/A Avidity Biosciences, Inc. 05370A108 19911.00000000 NS USD 1436180.43000000 1.317559412213 Long EC CORP US N 1 N N N Roivant Sciences Ltd. N/A Roivant Sciences Ltd. N/A 61011.00000000 NS USD 1323938.70000000 1.214588264079 Long EC CORP US N 1 N N N Arrowhead Pharmaceuticals Inc 549300O3CSB8T7OZ3D66 Arrowhead Pharmaceuticals, Inc. 04280A100 18776.00000000 NS USD 1246538.64000000 1.143581045606 Long EC CORP US N 1 N N N AbbVie Inc FR5LCKFTG8054YNNRU85 AbbVie, Inc. 00287Y109 35903.00000000 NS USD 8203476.47000000 7.525912072147 Long EC CORP US N 1 N N N Novo Nordisk A/S N/A Novo Nordisk A/S N/A 17387.00000000 NS USD 0.02000000 0.000000018348 Long CORP DK N 1 N N N Exelixis Inc 254900PJQB59O2O95R37 Exelixis, Inc. 30161Q104 34986.00000000 NS USD 1533436.38000000 1.406782527665 Long EC CORP US N 1 N N N Cidara Therapeutics Inc 549300IHQ9Z7RI1X2D22 Cidara Therapeutics, Inc. 171757206 4967.00000000 NS USD 1097160.63000000 1.006540880637 Long EC CORP US N 1 N N N Mirum Pharmaceuticals Inc 254900YZKR40F7F27K81 Mirum Pharmaceuticals, Inc. 604749101 8493.00000000 NS USD 670862.07000000 0.615452359718 Long EC CORP US N 1 N N N Natera Inc 529900CQ3OZ0A0VYVU59 Natera, Inc. 632307104 10785.00000000 NS USD 2470735.65000000 2.266665763401 Long EC CORP US N 1 N N N Scholar Rock Holding Corp 549300Z1FLPGL4OWJ459 Scholar Rock Holding Corp. 80706P103 18732.00000000 NS USD 825144.60000000 0.756991956899 Long EC CORP US N 1 N N N PTC Therapeutics Inc 549300UJLWOIWFDGB318 PTC Therapeutics, Inc. 69366J200 14278.00000000 NS USD 1084556.88000000 0.994978134693 Long EC CORP US N 1 N N N Guardant Health Inc 254900M8C3E5VC8BR186 Guardant Health, Inc. 40131M109 15544.00000000 NS USD 1587664.16000000 1.456531375686 Long EC CORP US N 1 N N N GRAIL Inc 2549009XSNESW3VE8024 GRAIL, Inc. 384747101 4486.00000000 NS USD 383956.74000000 0.352243914554 Long EC CORP US N 1 N N N Incyte Corp 549300Z4WN6JVZ3T4680 Incyte Corp. 45337C102 18317.00000000 NS USD 1809170.09000000 1.659742070412 Long EC CORP US N 1 N N N Alnylam Pharmaceuticals Inc 529900S3ZI14OWRJII50 Alnylam Pharmaceuticals, Inc. 02043Q107 7947.00000000 NS USD 3160124.55000000 2.899114733528 Long EC CORP US N 1 N N N Nuvalent Inc N/A Nuvalent, Inc. 670703107 6277.00000000 NS USD 631403.43000000 0.579252797714 Long EC CORP US N 1 N N N Arcutis Biotherapeutics Inc N/A Arcutis Biotherapeutics, Inc. 03969K108 27126.00000000 NS USD 787739.04000000 0.722675901188 Long EC CORP US N 1 N N N United Therapeutics Corp 5299005C4HZL4UWROC14 United Therapeutics Corp. 91307C102 4137.00000000 NS USD 2015753.25000000 1.849262538159 Long EC CORP US N 1 N N N Travere Therapeutics Inc N/A Travere Therapeutics, Inc. 89422G107 22050.00000000 NS USD 842530.50000000 0.772941872179 Long EC CORP US N 1 N N N Axsome Therapeutics Inc 549300EXGR0XLRJEIB95 Axsome Therapeutics, Inc. 05464T104 5927.00000000 NS USD 1082507.28000000 0.993097820970 Long EC CORP US N 1 N N N CRISPR Therapeutics AG 506700O6IRRIQLT3W370 CRISPR Therapeutics AG N/A 23590.00000000 NS USD 1237059.60000000 1.134884924903 Long EC CORP US N 1 N N N Jazz Pharmaceuticals PLC 635400GAUMJCLEZRRV50 Jazz Pharmaceuticals plc N/A 8580.00000000 NS USD 1458600.00000000 1.338127242587 Long EC CORP US N 1 N N N Soleno Therapeutics Inc 5493003LCY77N7FXK844 Soleno Therapeutics, Inc. 834203309 14213.00000000 NS USD 658061.90000000 0.603709417043 Long EC CORP US N 1 N N N 2026-01-30 Rydex Series Funds James Howley James Howley CFO XXXX