JOINT FILER INFORMATION Name: Frost Gamma Investments Trust Address: 4400 Biscayne Blvd. Miami, FL 33137 Designated Filer: Phillip Frost, M.D. Issuer Name and Ticker Symbol: OPKO Health, Inc. (OPK) Date of Earliest Transaction: January 23, 2020 Relationship to Issuer: 10% Owner FROST GAMMA INVESTMENTS TRUST By: /s/ Phillip Frost, M.D., as Trustee Phillip Frost, M.D., Trustee