X0306 4 2018-02-27 0 0000944809 Opko Health, Inc. OPK 0000898860 FROST PHILLIP MD ET AL OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI FL 33137 1 1 1 0 CEO & Chairman 0001380896 Frost Gamma Investments Trust 4400 BISCAYNE BLVD. MIAMI FL 33137 0 0 1 0 5% Convertible Promissory Note 5.00 2018-02-27 4 A 0 25000000.00 25000000.00 A 2023-02-27 Common Stock 5000000 25000000.00 I See Footnote The Reporting Person has the option, from time to time, to convert all or any portion of the outstanding principal balance of the 5% Convertible Promissory Note (the "Note"), together with accrued and unpaid interest thereon, into shares of the Issuer's common stock, par value $0.01 per share ("Common Stock"), at a conversion price of $5.00 per share of Common Stock. The Note may be converted at any time prior to the Maturity Date. The Notes will mature on February 27, 2023, unless repurchased, redeemed or converted prior to such date. Based on the principal amount of the Note, excluding shares issuable upon conversion of accrued and unpaid interest as of the date of conversion. The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. Phillip Frost, M.D., Individually and as Trustee 2018-03-01