X0202 4 2004-11-15 0 0000898437 ANIKA THERAPEUTICS INC ANIK 0001308956 Toth Carol A C/O ANIKA THERAPEUTICS, INC. 160 NEW BOSTON STREET WOBURN MA 01801 0 1 0 0 Vice President, R & D Stock Option (Right to Purchase) 9.64 2004-11-15 4 A 0 75000 9.64 A 2014-11-15 Common Stock 75000 75000 D The Stock Option is exercisable in four equal annual installments beginning November 15, 2005. /s/ Carol A. Toth 2004-11-17