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Note 9 - Intangible Assets (Details Textual) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2019
Mar. 31, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Amortization of Intangible Assets, Total $ 300   $ 200 $ 800 $ 800  
Impairment of Intangible Assets, Finite-lived       303  
Intangible Assets, Net (Excluding Goodwill), Total 7,680     7,680   $ 9,191
HYALOSPINE Developed Technology Asset [Member]            
Impairment of Intangible Assets, Finite-lived   $ 300        
MEROGEL INJECTIBLE Assets [Member]            
Intangible Assets, Net (Excluding Goodwill), Total $ 100     $ 100