X0306 4 2017-11-30 0 0000898437 Anika Therapeutics, Inc. ANIK 0001656557 Hague Richard 32 WIGGINS AVENUE BEDFORD MA 01730 0 1 0 0 Chief Commercial Officer Common Stock 2017-11-30 4 S 0 5250 54.48 D 23650 D On November 30, 2017, Mr. Hague sold 5,250 shares in multiple trades ranging from $54.20 to $54.98. The price reported above reflects the weighted average sale price. Mr. Hague undertakes to provide the Securities and Exchange Commission staff, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares and prices at which the transactions were effected. /s/ Richard Hague 2017-12-01