X0306 4 2017-10-20 0 0000898437 Anika Therapeutics, Inc. ANIK 0001244298 SHERWOOD CHARLES H 32 WIGGINS AVENUE BEDFORD MA 01730 1 1 0 0 CEO and Director Common Stock 2017-10-20 4 S 0 5991 60.04 D 158297 D Common Stock 2017-10-23 4 S 0 22228 60.06 D 136069 D On October 20, 2017, pursuant to a plan of disposition adopted in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934 on February 21, 2017, Dr. Sherwood sold 5,991 shares in multiple trades ranging from $60.00 to $60.13. The price reported above reflects the weighted average sale price. Dr. Sherwood undertakes to provide the Securities and Exchange Commission staff, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares and prices at which the transactions were effected. On October 23, 2017, pursuant to a plan of disposition adopted in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934 on February 21, 2017, Dr. Sherwood sold 22,228 shares in multiple trades ranging from $60.00 to $60.22. The price reported above reflects the weighted average sale price. Dr. Sherwood undertakes to provide the Securities and Exchange Commission staff, the issuer or any security holder of the issuer, upon request, full information regarding the number of shares and prices at which the transactions were effected. /s/ Charles H. Sherwood, Ph.D. 2017-10-24