X0306 4 2018-01-02 0000874015 IONIS PHARMACEUTICALS INC IONS 0000897667 CROOKE STANLEY T C/O IONIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 1 1 0 0 Chairman and CEO Employee Stock Option (right to buy) 49.25 2018-01-02 2018-01-02 4 A 0 158175 0 A 2019-01-02 2025-01-02 Common Stock 158175 158175 D Employee Stock Option (right to buy) 49.25 2018-01-02 2018-01-02 4 A 0 17603 0 A 2019-01-02 2025-01-01 Common Stock 17603 17603 I By wife Grant of 1/2/2018 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 1/2/2019. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 39,544 shares per year. Following this transaction, the option was exercisable as to 0 on 1/2/2018. Grant of 1/2/2018 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 1/2/2019. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 4,401 shares per year. Following this transaction, the option was exercisable as to 0 on 1/2/2018. /s/B. Lynne Parshall, attorney-in-fact 2018-01-02