X0306 4 2017-01-15 0000874015 IONIS PHARMACEUTICALS INC IONS 0000897667 CROOKE STANLEY T C/O IONIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 1 1 0 0 Chairman and CEO Common Stock 2017-01-15 2017-01-15 4 M 0 5547 0 A 30576 D Common Stock 2017-01-17 2017-01-17 4 S 0 3008 46.289 D 27568 D Common Stock 2017-01-15 2017-01-15 4 M 0 7812 0 A 35380 D Common Stock 2017-01-17 2017-01-17 4 S 0 4236 46.289 D 31144 D Common Stock 2017-01-15 2017-01-15 4 M 0 6875 0 A 38019 D Common Stock 2017-01-17 2017-01-17 4 S 0 3728 46.29 D 34291 D Common Stock 2017-01-15 2017-01-15 4 M 0 8133 0 A 42424 D Common Stock 2017-01-17 2017-01-17 4 S 0 4410 46.29 D 38014 D Common Stock 2017-01-15 2017-01-15 4 M 0 416 0 A 2586 I By wife Common Stock 2017-01-17 2017-01-17 4 S 0 163 46.291 D 2423 I By wife Common Stock 2017-01-15 2017-01-15 4 M 0 354 0 A 2777 I By wife Common Stock 2017-01-17 2017-01-17 4 S 0 139 46.29 D 2638 I By wife Common Stock 2017-01-15 2017-01-15 4 M 0 363 0 A 3001 I By wife Common Stock 2017-01-17 2017-01-17 4 S 0 142 46.291 D 2859 I By wife Common Stock 2017-01-15 2017-01-15 4 M 0 334 0 A 3193 I By wife Common Stock 2017-01-17 2017-01-17 4 S 0 131 46.29 D 3062 I By wife Common Stock 725391 I By trust Restricted Stock Units 2017-01-15 2017-01-15 4 A 0 27168 0 A Common Stock 27168 27168 D Restricted Stock Units 2017-01-15 2017-01-15 4 A 0 2692 0 A Common Stock 2692 2692 I By wife Restricted Stock Units 2017-01-15 2017-01-15 4 M 0 5547 0 D Common Stock 5547 0 D Restricted Stock Units 2017-01-15 2017-01-15 4 M 0 7812 0 D Common Stock 7812 7812 D Restricted Stock Units 2017-01-15 2017-01-15 4 M 0 6875 0 D Common Stock 6875 13750 D Restricted Stock Units 2017-01-15 2017-01-15 4 M 0 8133 0 D Common Stock 8133 24397 D Restricted Stock Units 2017-01-15 2017-01-15 4 M 0 416 0 D Common Stock 416 0 I By wife Restricted Stock Units 2017-01-15 2017-01-15 4 M 0 354 0 D Common Stock 354 354 I By wife Restricted Stock Units 2017-01-15 2017-01-15 4 M 0 363 0 D Common Stock 363 724 I By wife Restricted Stock Units 2017-01-15 2017-01-15 4 M 0 334 0 D Common Stock 334 999 I By wife Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit award granted on January 30, 2013. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 30, 2013. Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit award granted on January 15, 2014. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2014. Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit award granted on January 15, 2015. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2015. Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit award granted on January 15, 2016. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2016. Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit award granted on January 15, 2013. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2013. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Grant 1/15/2017 to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on January 15, 2018. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2021. The RSU is vested as to 0 shares on January 15, 2017. Grant 1/15/2017 to reporting person's wife of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on January 15, 2018. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2021. The RSU is vested as to 0 shares on January 15, 2017. Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. /s/B. Lynne Parshall, attorney-in-fact 2017-01-18