X0306 4 2016-01-15 0000874015 IONIS PHARMACEUTICALS INC IONS 0000897667 CROOKE STANLEY T C/O IONIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 1 1 0 0 Chairman and CEO Common Stock 2016-01-15 2016-01-15 4 M 0 2977 0 A 17619 D Common Stock 2016-01-19 2016-01-19 4 S 0 1645 41.4582 D 15974 D Common Stock 2016-01-15 2016-01-15 4 M 0 5547 0 A 21521 D Common Stock 2016-01-19 2016-01-19 4 S 0 3065 41.4582 D 18456 D Common Stock 2016-01-15 2016-01-15 4 M 0 7813 0 A 26269 D Common Stock 2016-01-19 2016-01-19 4 S 0 4317 41.4551 D 21952 D Common Stock 2016-01-15 2016-01-15 4 M 0 6875 0 A 28827 D Common Stock 2016-01-19 2016-01-19 4 S 0 3798 41.4655 D 25029 D Common Stock 2016-01-15 2016-01-15 4 M 0 316 0 A 1613 I By wife Common Stock 2016-01-19 2016-01-19 4 S 0 124 41.461 D 1489 I By wife Common Stock 2016-01-15 2016-01-15 4 M 0 416 0 A 1905 I By wife Common Stock 2016-01-19 2016-01-19 4 S 0 166 41.4626 D 1739 I By wife Common Stock 2016-01-15 2016-01-15 4 M 0 354 0 A 2093 I By wife Common Stock 2016-01-19 2016-01-19 4 S 0 141 41.4633 D 1952 I By wife Common Stock 2016-01-15 2016-01-15 4 M 0 363 0 A 2315 I By wife Common Stock 2016-01-19 2016-01-19 4 S 0 145 41.46 D 2170 I By wife Common Stock 725391 I By trust Restricted Stock Units 2016-01-15 2016-01-15 4 A 0 32530 0 A Common Stock 32530 32530 D Restricted Stock Units 2016-01-15 2016-01-15 4 A 0 1333 0 A Common Stock 1333 1333 I By wife Restricted Stock Units 2016-01-15 2016-01-15 4 M 0 2977 0 D Common Stock 2977 0 D Restricted Stock Units 2016-01-15 2016-01-15 4 M 0 5547 0 D Common Stock 5547 5547 D Restricted Stock Units 2016-01-15 2016-01-15 4 M 0 7813 0 D Common Stock 7813 15624 D Restricted Stock Units 2016-01-15 2016-01-15 4 M 0 6875 0 D Common Stock 6875 20625 D Restricted Stock Units 2016-01-15 2016-01-15 4 M 0 316 0 D Common Stock 316 0 I By wife Restricted Stock Units 2016-01-15 2016-01-15 4 M 0 416 0 D Common Stock 416 416 I By wife Restricted Stock Units 2016-01-15 2016-01-15 4 M 0 354 0 D Common Stock 354 708 I By wife Restricted Stock Units 2016-01-15 2016-01-15 4 M 0 363 0 D Common Stock 363 1087 I By wife Acquired pursuant to vesting and release of shares pursuant to an RSU award granted on January 15, 2012. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2012. Acquired pursuant to vesting and release of shares pursuant to an RSU award granted on January 30, 2013. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 30, 2013. Acquired pursuant to vesting and release of shares pursuant to an RSU award granted on January 15, 2014. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2014. Acquired pursuant to vesting and release of shares pursuant to an RSU award granted on January 15, 2015. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2015. Acquired pursuant to vesting and release of shares pursuant to an RSU award granted on January 15, 2013. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2013. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Grant 1/15/2016 to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on January 15, 2017. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2020. The RSU is vested as to 0 shares on January 15, 2016. Grant 1/15/2016 to reporting person's wife of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on January 15, 2017. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2020. The RSU is vested as to 0 shares on January 15, 2016. Restricted Stock Unit Award granted on January 15, 2012. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2013. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU was fully vested on January 15, 2016. Restricted Stock Unit Award granted on January 30, 2013. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2014. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2017. Restricted Stock Unit Award granted on January 15, 2014. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2015. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2018. Restricted Stock Unit Award granted on January 15, 2015. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2016. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2019. Restricted Stock Unit Award granted on January 15, 2013. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2014. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2017. /s/B. Lynne Parshall, attorney-in-fact 2016-01-19