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Debt - Debt from Royalty-Bearing Instrument-December 2012 Financing - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Dec. 06, 2012
Nov. 30, 2020
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Debt Disclosure [Line Items]          
Outstanding debt     $ 0 $ 50,130,000  
Interest expense, non-cash     635,000 1,644,000 $ 2,183,000
CPPIB          
Debt Disclosure [Line Items]          
Repayment of debt     150,000,000.0    
Repayment under agreement   $ 9,600,000 52,400,000    
BioPharma Debt          
Debt Disclosure [Line Items]          
Amount received at the closing of the agreement $ 100,000,000.0        
Maximum repayment of future revenue and receivables $ 150,000,000.0        
Royalty-Bearing Debt | Cash          
Debt Disclosure [Line Items]          
Interest expense, contractual coupon interest     1,600,000 4,400,000  
Royalty-Bearing Debt | Non Cash          
Debt Disclosure [Line Items]          
Interest expense, non-cash     $ 600,000 $ 1,600,000