Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Statement [Abstract]
Product revenue, net	$ 179,825	$ 128,966	$ 80,987
Licensing revenue	1,279	1,118	769
Total revenue, net	181,104	130,084	81,756
Less: Cost of goods sold	44,952	34,363	27,875
Gross margin	136,152	95,721	53,881
Operating expenses:
Selling, general and administrative	134,549	111,372	101,041
Research and development	47,158	49,975	51,062
Total operating expenses	181,707	161,347	152,103
Operating loss	(45,555)	(65,626)	(98,222)
Gain (loss) on change in fair value of derivative liabilities		8,170	(1,106)
Gain on extinguishment of debt			1,314
Interest expense	(9,766)	(18,677)	(20,180)
Interest income	429	234	132
Other income (expense), net	74	(482)	(228)
Loss from operations before taxes	(54,818)	(76,381)	(118,290)
(Provision for) benefit from income taxes	(13,047)	(9,969)	3,086
Net loss	(67,865)	(86,350)	(115,204)
Preferred stock purchase option			(868)
Preferred stock beneficial conversion features			(32,987)
Net loss applicable to common shareholders	$ (67,865)	$ (86,350)	$ (149,059)
Loss per share:
Basic	$ (0.25)	$ (0.41)	$ (0.83)
Diluted	$ (0.25)	$ (0.41)	$ (0.83)
Weighted average shares outstanding:
Basic	270,652	211,874	180,654
Diluted	270,652	211,874	180,654