Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2017

Accounting Policies [Abstract]

Summarize Activity of the Net Product Revenue Allowance and Reserve Categories

The following table summarizes activity in each of the net product revenue allowance and reserve categories described above for the years ended December 31, 2017 and 2016:

In thousands	Trade Allowances			Rebates, Chargebacks and Discounts			Product Returns			Other Incentives			Total
Balance as of January 1, 2016	$	4,296		$	9,881		$	535		$	1,084		$	15,796
Provision related to current period sales		22,952			69,370			583			11,696			104,601
Provision related to prior period sales		(87	)		(450	)		—			—			(537	)
Credits/payments made for current period sales		(19,213	)		(48,719	)		—			(9,815	)		(77,747	)
Credits/payments made for prior period sales		(4,205	)		(9,167	)		(259	)		(1,284	)		(14,915	)
Balance as of December 31, 2016		3,743			20,915			859			1,681			27,198
Provision related to current period sales		35,067			126,903			1,480			15,081			178,531
Provision related to prior period sales		(323	)		(682	)		—			(70	)		(1,075	)
Credits/payments made for current period sales		(23,087	)		(96,181	)		(344	)		(12,773	)		(132,385	)
Credits/payments made for prior period sales		(3,365	)		(18,891	)		(108	)		(1,812	)		(24,176	)
Balance as of December 31, 2017	$	12,035		$	32,064		$	1,887		$	2,107		$	48,093

Summarizes the Impact of Accounts Receivable Reserves on Gross Trade Accounts Receivable

The following table summarizes the impact of accounts receivable reserves on the gross trade accounts receivable balances as of December 31, 2017 and 2016:

In thousands	December 31, 2017			December 31, 2016
Gross trade accounts receivable	$	57,802		$	24,127
Trade allowances		(12,035	)		(3,743	)
Chargebacks		(449	)		(387	)
Allowance for doubtful accounts		—			(12	)
Accounts receivable, net	$	45,318		$	19,985

Estimated Useful Lives

The estimated useful lives, by asset classification, are as follows:

Asset Classification	Useful Lives
Computer equipment and software	3 - 5 years
Furniture and fixtures	5 years
Leasehold improvements	Lesser of useful life or lease term

Net Loss and the Number of Shares Used to Compute Basic and Diluted Net Loss per Share

The calculation of net loss and the number of shares used to compute basic and diluted net loss per share for the years ended December 31, 2017, 2016 and 2015 are as follows:

In thousands	2017			2016			2015
Net loss	$	(67,865	)	$	(86,350	)	$	(115,204	)
Preferred stock purchase option (see Note 10—Equity)		—			—			(868	)
Preferred stock beneficial conversion features (see Note 10—Equity)		—			—			(32,987	)
Net loss applicable to common shareholders—basic and diluted		(67,865	)		(86,350	)		(149,059	)
Weighted average shares outstanding—basic and diluted		270,652			211,874			180,654
Net loss per share—basic and diluted	$	(0.25	)	$	(0.41	)	$	(0.83	)

Anti-Dilutive Securities Not Included in the Computation of Net Loss or Earnings per Share

For the years ended December 31, 2017, 2016 and 2015, the following potentially dilutive securities were not included in the computation of net loss per share because the effect would be anti-dilutive:

In thousands	2017		2016		2015
Stock options		24,108		21,188		17,818
Restricted stock and restricted stock units		12,006		10,143		10,887
Exchangeable senior notes (if converted)		7,716		1,714		59,407
Preferred stock (if converted)		32,818		32,818		32,818

Assets and Liability Measured at Fair Value on a Recurring Basis

The following tables present information about the Company’s assets and liabilities as of December 31, 2017 and 2016 that are measured at fair value on a recurring basis and indicate the fair value hierarchy of the valuation techniques the Company utilized to determine such fair value:

	December 31, 2017
In thousands	Total		Level 1		Level 2		Level 3
Asset:
Cash equivalents—money markets	$	9,317	$	9,317	$	—	$	—

	December 31, 2016
In thousands	Total		Level 1		Level 2		Level 3
Asset:
Cash equivalents—money markets	$	14,238	$	14,238	$	—	$	—

Carrying Amounts and Estimated Fair Values of Debt Instruments

The carrying amounts of cash, cash equivalents, accounts payable and accrued liabilities approximate fair value because of their short-term nature. The carrying amounts and the estimated fair values of debt instruments as of December 31, 2017 and 2016 are as follows:

	December 31, 2017				December 31, 2016
In thousands	Carrying Value		Estimated Fair Value		Carrying Value		Estimated Fair Value
Current portion of long-term debt from royalty-bearing      instrument, net of accrued interest	$	21,569			$	8,437
Long-term debt from royalty-bearing instrument		70,834				85,155
Total long-term debt from royalty-bearing instrument	$	92,403	$	88,000	$	93,592	$	90,500
2012 Notes		—		—		15,107		15,174
2017 Notes		28,992		38,200		—		—