Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2025

Accounting Policies [Abstract]

Summary of Impact of Accounts Receivable Reserves on Gross Trade Accounts Receivable Balances

The following table summarizes the impact of accounts receivable reserves on the gross trade accounts receivable balances as of September 30, 2025 and December 31, 2024:

In thousands	September 30, 2025			December 31, 2024
Gross trade accounts receivable	$	141,296		$	133,072
Trade allowances		(12,774	)		(9,433	)
Chargebacks		(1,213	)		(1,360	)
Accounts receivable, net	$	127,309		$	122,279

Calculation of Net Loss and Number of Ordinary Shares and ADSs Used to Compute Basic and Diluted Net Loss per Ordinary Share and ADS

The calculation of net loss and the number of Ordinary Shares and ADSs used to compute basic and diluted net loss per Ordinary Share and ADS for the three and nine months ended September 30, 2025 and 2024 are as follows:

	For the Three Months Ended September 30,						For the Nine Months Ended September 30,
In thousands	2025			2024			2025			2024
Net loss—basic and diluted	$	(7,738	)	$	(25,134	)	$	(37,574	)	$	(33,565	)
Weighted average Ordinary Shares outstanding—basic and diluted		415,531			411,150			414,607			410,786
Loss per Ordinary Share—basic and diluted (1)	$	(0.02	)	$	(0.06	)	$	(0.09	)	$	(0.08	)
Weighted average ADS outstanding—basic and diluted		20,776			20,557			20,730			20,539
Loss per ADS—basic and diluted (1)	$	(0.37	)	$	(1.22	)	$	(1.81	)	$	(1.63	)

(1) Excluding the licensing revenue change in estimates, discussed in Note 7 – Revenue Recognition, net loss per ordinary share, basic and diluted, for the nine months ended September 30, 2024 would have been net loss per share of $(0.09) and net loss per ADS, basic and diluted for the nine months ended September 30, 2024 would have been net loss per share of $(1.84).

Anti-Dilutive Securities Not Included in the Computation of Net Loss per Share

For the three and nine months ended September 30, 2025 and 2024, the following potentially dilutive securities were not included in the computation of net loss per share because the effect would be anti-dilutive or because performance criteria were not yet met for awards contingent upon such measures:

	For the Three Months Ended September 30,				For the Nine Months Ended September 30,
In thousands	2025		2024		2025		2024
Stock options		30,769		29,071		30,769		29,071
Restricted stock units		14,726		14,926		14,726		14,926

Estimated Fair Value of Assets and Liability

The following tables present information about the estimated fair value of the Company’s assets and liabilities as of September 30, 2025 and December 31, 2024, and indicate the fair value hierarchy of the valuation techniques the Company utilized to determine such fair value:

	September 30, 2025
In thousands	Total		Level 1		Level 2		Level 3
Asset:
U.S. Treasury Securities	$	172,822	$	172,822	$	—	$	—
Money Market Fund		38,765		38,765		—		—
Repo Securities		5,000		—		5,000		—
Total	$	216,587	$	211,587	$	5,000	$	—

	December 31, 2024
In thousands	Total		Level 1		Level 2		Level 3
Asset:
U.S. Treasury Securities	$	174,722	$	174,722	$	—	$	—
Money Market Fund		67,456		67,456		—		—
Repo Securities		5,000		—		5,000		—
Total	$	247,178	$	242,178	$	5,000	$	—

Schedule of Reportable Segment Profit or Loss Including Significant Reportable Segment Expenses

The table below is a summary of the reportable segment profit or loss, including significant reportable segment expenses:

	For the Three Months Ended September 30,						For the Nine Months Ended September 30,
In thousands	2025			2024			2025			2024
US product revenue, net	$	40,866		$	30,601		$	113,028		$	122,471
Europe product revenue, net		4,095			4,332			16,060			9,732
RoW product revenue, net		3,597			6,919			7,122			12,319
Total product revenue, net		48,558			41,852			136,210			144,522
Licensing and royalty revenue		1,112			446			28,217			21,786
Total revenue, net		49,670			42,298			164,427			166,308
Less: Cost of goods sold		27,462			26,022			66,728			75,359
Gross margin		22,208			16,276			97,699			90,949
Operating expenses:
Selling		2,722			9,107			18,582			29,579
General and administrative		9,012			9,693			32,185			28,498
Research and development		1,289			1,425			5,216			5,268
Payroll and payroll related expense		8,528			16,521			43,250			52,576
Non-cash stock-based compensation expense		2,354			4,698			10,146			14,303
Restructuring		9,406			—			32,165			—
Total operating expenses		33,311			41,444			141,544			130,224
Operating loss		(11,103	)		(25,168	)		(43,845	)		(39,275	)
Interest income, net		2,783			3,374			8,277			10,028
Other income, net		205			265			372			1,954
Loss from operations before taxes		(8,115	)		(21,529	)		(35,196	)		(27,293	)
Benefit from (provision for) income taxes		377			(3,605	)		(2,378	)		(6,272	)
Segment & consolidated net loss	$	(7,738	)	$	(25,134	)	$	(37,574	)	$	(33,565	)

Summary of Restructuring Charges

The following table sets forth the components of the Company's restructuring charges for the three and nine months ended September 30, 2025 (none in 2024):

	For the Three Months Ended September 30,			For the Nine Months Ended September 30,
In thousands	2025			2025
Restructuring expense	$	10,714		$	23,428
Vendor contract charges		(1,308	)		8,737
Total restructuring expense		9,406			32,165
Forfeited (accelerated) stock vesting		399			(2,176	)
Total restructuring costs incurred	$	9,805		$	29,989

Change in Restructuring Liability

The following table shows the change in restructuring liability, which is included within accrued expenses and other current liabilities:

In thousands	Restructuring Liability
Balance at December 31, 2024	$	—
Costs incurred		29,989
Payments		(17,190	)
Balance at September 30, 2025	$	12,799