Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2025

Accounting Policies [Abstract]

Summary of Impact of Accounts Receivable Reserves on Gross Trade Accounts Receivable Balances

The following table summarizes the impact of accounts receivable reserves on the gross trade accounts receivable balances as of June 30, 2025 and December 31, 2024:

In thousands	June 30, 2025			December 31, 2024
Gross trade accounts receivable	$	134,104		$	133,072
Trade allowances		(13,626	)		(9,433	)
Chargebacks		(1,348	)		(1,360	)
Accounts receivable, net	$	119,130		$	122,279

Calculation of Net (Loss) Income and Number of Ordinary Shares and ADSs Used to Compute Basic and Diluted Net (Loss) Earnings per Ordinary Share and ADS

The calculation of net (loss) income and the number of Ordinary Shares and ADSs used to compute basic and diluted net (loss) earnings per Ordinary Share and ADS for the three and six months ended June 30, 2025 and 2024 are as follows:

	For the Three Months Ended June 30,					For the Six Months Ended June 30,
In thousands	2025			2024		2025			2024
Net (loss) income—basic and diluted	$	(14,139	)	$	1,522	$	(29,836	)	$	(8,431	)
Weighted average Ordinary Shares outstanding—basic and diluted		414,477			410,851		414,008			410,565
Effect of dilutive securities:
Restricted stock units		—			545		—			—
Weighted average shares outstanding—diluted		414,477			411,395		414,008			410,565
(Loss) earnings per Ordinary Share—basic and diluted (1)	$	(0.03	)	$	0.00	$	(0.07	)	$	(0.02	)
Weighted average ADS outstanding—basic and diluted		20,723			20,542		20,700			20,528
(Loss) earnings per ADS—basic and diluted (1)	$	(0.68	)	$	0.07	$	(1.44	)	$	(0.41	)

(1) Excluding the licensing revenue change in estimates, discussed in Note 7 – Revenue Recognition, net earnings (loss) per ordinary share, basic and diluted, for the three and six months ended June 30, 2024 would have been net loss per share of $(0.01) and $(0.03), respectively and net earnings (loss) per ADS, basic and diluted for the three and six months ended June 30, 2024 would have been net loss per share of $(0.13) and $(0.61), respectively.

Anti-Dilutive Securities Not Included in the Computation of Net (Loss) Earnings per Share

For the three and six months ended June 30, 2025 and 2024, the following potentially dilutive securities were not included in the computation of net (loss) earnings per share because the effect would be anti-dilutive or because performance criteria were not yet met for awards contingent upon such measures:

	For the Three Months Ended June 30,				For the Six Months Ended June 30,
In thousands	2025		2024		2025		2024
Stock options		31,103		24,792		31,103		25,337
Restricted stock units		19,279		14,926		19,279		14,926

Estimated Fair Value of Assets and Liability

The following tables present information about the estimated fair value of the Company’s assets and liabilities as of June 30, 2025 and December 31, 2024, and indicate the fair value hierarchy of the valuation techniques the Company utilized to determine such fair value:

	June 30, 2025
In thousands	Total		Level 1		Level 2		Level 3
Asset:
U.S. Treasury Securities	$	150,822	$	150,822	$	—	$	—
Money Market Fund		58,470		58,470		—		—
Repo Securities		5,000		—		5,000		—
Total	$	214,292	$	209,292	$	5,000	$	—

	December 31, 2024
In thousands	Total		Level 1		Level 2		Level 3
Asset:
U.S. Treasury Securities	$	174,722	$	174,722	$	—	$	—
Money Market Fund		67,456		67,456		—		—
Repo Securities		5,000		—		5,000		—
Total	$	247,178	$	242,178	$	5,000	$	—

Schedule of Reportable Segment Profit or Loss Including Significant Reportable Segment Expenses

The table below is a summary of the reportable segment profit or loss, including significant reportable segment expenses:

	For the Three Months Ended June 30,						For the Six Months Ended June 30,
In thousands	2025			2024			2025			2024
US product revenue, net	$	36,502		$	43,758		$	72,162		$	91,872
Europe product revenue, net		6,572			3,543			11,965			5,408
RoW product revenue, net		3,543			213			3,525			5,390
Total product revenue, net		46,617			47,514			87,652			102,670
Licensing and royalty revenue		26,124			19,977			27,105			21,340
Total revenue, net		72,741			67,491			114,757			124,010
Less: Cost of goods sold		22,379			24,722			39,266			49,337
Gross margin		50,362			42,769			75,491			74,673
Operating expenses:
Selling		8,476			10,223			15,860			20,472
General and administrative		14,524			9,390			23,173			18,805
Research and development		1,884			1,626			3,928			3,843
Payroll and payroll related expense		15,239			17,667			34,722			36,055
Non-cash stock-based compensation expense		3,465			4,387			7,791			9,605
Restructuring		22,759			—			22,759			—
Total operating expenses		66,347			43,293			108,233			88,780
Operating loss		(15,985	)		(524	)		(32,742	)		(14,107	)
Interest income, net		2,620			3,271			5,493			6,654
Other (expense) income, net		(85	)		145			168			1,689
(Loss) income from operations before taxes		(13,450	)		2,892			(27,081	)		(5,764	)
Provision for income taxes		(689	)		(1,370	)		(2,755	)		(2,667	)
Segment & consolidated net (loss) income	$	(14,139	)	$	1,522		$	(29,836	)	$	(8,431	)

Summary of Restructuring Charges

The following table sets forth the components of the Company's restructuring charges for the three and six months ended June 30, 2024 (none in 2024):

	For the Three Months Ended June 30,			For the Six Months Ended June 30,
In thousands	2025			2025
Restructuring expense	$	12,714		$	12,714
Vendor contract charges		10,045			10,045
Total restructuring expense		22,759			22,759
Accelerated stock vesting		(2,575	)		(2,575	)
Total restructuring costs incurred	$	20,184		$	20,184

Change in Restructuring Liability

The following table shows the change in restructuring liability, which is included within accrued expenses and other current liabilities:

In thousands	Restructuring Liability
Balance at December 31, 2024	$	—
Costs incurred		20,184
Other		337
Balance at June 30, 2025	$	20,521