Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2023

Accounting Policies [Abstract]

Summary of Impact of Accounts Receivable Reserves on Gross Trade Accounts Receivable Balances

The following table summarizes the impact of accounts receivable reserves on the gross trade accounts receivable balances as of June 30, 2023 and December 31, 2022:

In thousands	June 30, 2023			December 31, 2022
Gross trade accounts receivable	$	155,098		$	187,418
Trade allowances		(21,528	)		(44,626	)
Chargebacks		(10,840	)		(11,802	)
Accounts receivable, net	$	122,730		$	130,990

Calculation of Net Loss and Number of Shares Used to Compute Basic and Diluted Net Loss per Share

The calculation of net loss and the number of shares used to compute basic and diluted net loss per share for the three and six months ended June 30, 2023 and 2022 are as follows:

	For the Three Months Ended June 30,						For the Six Months Ended June 30,
In thousands	2023			2022			2023			2022
Net loss—basic and diluted	$	(17,560	)	$	(69,956	)	$	(34,020	)	$	(101,519	)
Weighted average shares outstanding—basic and diluted		407,848			398,187			407,017			397,997
Net loss per share—basic and diluted (1)	$	(0.04	)	$	(0.18	)	$	(0.08	)	$	(0.26	)

(1) Excluding the licensing revenue change in estimate, as discussed in Note 8 - Development, Commercialization and Supply Agreements, net loss per share basic and diluted for the three and six months ended June 30, 2023 would have been $(0.06) and $(0.10), respectively.

Anti-Dilutive Securities Not Included in the Computation of Net Loss per Share

For the three and six months ended June 30, 2023 and 2022, the following potentially dilutive securities were not included in the computation of net loss per share because the effect would be anti-dilutive or because performance criteria were not yet met for awards contingent upon such measures:

	For the Three Months Ended June 30,				For the Six Months Ended June 30,
In thousands	2023		2022		2023		2022
Stock options		16,000		19,995		16,000		19,995
Restricted stock and restricted stock units		14,903		15,024		14,903		15,024
Laxdale milestone shares		—		6,667		—		6,667

Estimated Fair Value of Assets and Liability

The following tables present information about the estimated fair value of the Company’s assets and liabilities as of June 30, 2023 and December 31, 2022 and indicate the fair value hierarchy of the valuation techniques the Company utilized to determine such fair value:

	June 30, 2023
In thousands	Total		Level 1		Level 2		Level 3
Asset:
Money Market Fund	$	136,995	$	136,995	$	—	$	—
Commercial Paper		65,660		—		65,660		—
Agency Securities		12,258		2,424		9,834		—
Certificate of Deposit		4,099		—		4,099		—
Corporate Bonds		3,610		—		3,610		—
Repo Securities		3,250		—		3,250		—
U.S. Treasury Securities		3,185		3,185		—		—
Asset-Backed Securities		96		—		96		—
Total	$	229,153	$	142,604	$	86,549	$	-

	December 31, 2022
In thousands	Total		Level 1		Level 2		Level 3
Asset:
Money Market Fund	$	81,870	$	81,870	$	—	$	—
Commercial Paper		62,347		—		62,347		—
Corporate Bonds		28,416		—		28,416		—
Certificate of Deposit		9,100		—		9,100		—
Repo Securities		3,250		—		3,250		—
U.S. Treasury Securities		3,117		3,117		—		—
Agency Securities		1,554		1,554		—		—
Non-US Government Securities		1,393		—		1,393		—
Asset-Backed Securities		1,260		—		1,260		—
Total	$	192,307	$	86,541	$	105,766	$	—

Summary of Restructuring Charges

The following table sets forth the components of the Company's restructuring charges for the three and six months ended June 30, 2023 and 2022:

	For the Three Months Ended June 30,					For the Six Months Ended June 30,
In thousands	2023			2022		2023			2022
Employee restructuring separation charges	$	10,154		$	9,123	$	10,154		$	9,123
Vendor contract charges		(122	)		1,090		(122	)		1,090
Total restructuring expense		10,032			10,213		10,032			10,213
Restructuring inventory		14,300			15,000		26,554			15,000
Stock forfeitures		—			454		—			454
Total restructuring costs incurred	$	24,332		$	25,667	$	36,586		$	25,667

Change in Restructuring Liability

The following table shows the change in restructuring liability which is included within accrued expenses and other current liabilities:

In thousands	Restructuring Liability
Balance at December 31, 2022	$	192
Costs incurred		36,586
Payments		(10,324	)
Balance at June 30, 2023	$	26,454