Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
CASH FLOWS FROM OPERATING ACTIVITIES:
Net (loss) income	$ (105,803)	$ 7,729	$ (18,000)
Adjustments to reconcile net (loss) income to net cash used in operating activities:
Depreciation and amortization	551	587	597
Amortization of investments	473	1,929	1,602
Stock-based compensation	26,213	36,938	45,813
Amortization of debt discount and debt issuance costs			635
Amortization of intangible asset	2,545	2,270	1,441
Changes in assets and liabilities:
Accounts receivable, net	32,663	(9,079)	(38,144)
Inventory	(36,422)	(167,066)	(112,095)
Prepaid and other current assets	2,860	8,595	(17,636)
Other long-term assets	(2)	(24)	642
Interest receivable	341	738	(1,329)
Accrued interest payable			(428)
Deferred revenue	(1,363)	(1,923)	(2,214)
Accounts payable, accrued expenses and other current liabilities	(102,729)	51,516	114,741
Other long-term liabilities	581	1,253	2,629
Net cash used in operating activities	(180,092)	(66,537)	(21,746)
CASH FLOWS FROM INVESTING ACTIVITIES:
Sale and maturities of securities	257,520	394,294	301,989
Purchases of securities	(81,633)	(290,195)	(678,700)
Investment in website development costs	(599)
Disposal (purchases) of furniture, fixtures and equipment		4	(252)
Net cash provided by (used in) investing activities	175,288	104,103	(376,963)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock under employee stock purchase plan	605	1,650	1,957
Proceeds from exercise of stock options, net of transaction costs	60	2,921	5,158
Payment of transaction costs for conversion of preferred stock			(504)
Payment on debt from royalty-bearing instrument			(50,336)
Taxes related to stock-based awards	(1,044)	(9,644)	(15,182)
Net cash used in financing activities	(379)	(5,073)	(58,907)
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH	(5,183)	32,493	(457,616)
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD	223,372	190,879	648,495
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD	218,189	223,372	190,879
Cash (paid) received during the year for:
Interest			(2,043)
Income taxes	(1,782)	3,656	(207)
Supplemental disclosure of non-cash transactions:
Laxdale milestone		$ 12,000
Shares issued in settlement of Laxdale milestone payment	8,203
Initial recognition of operating lease right-of-use asset	$ 2,041
Conversion of Series A Convertible Preferred Stock into common stock			$ 18,020