Commitments and Contingencies - Additional Information (Detail) $ in Thousands	Dec. 31, 2022 USD ($)	Dec. 31, 2022 GBP (£)	Jul. 13, 2022 GBP (£)	Dec. 31, 2021 USD ($)	Mar. 26, 2021 GBP (£)
Commitments And Contingencies Disclosure [Line Items]
Potential payable amount over the agreement terms based on minimum purchase obligation | $	$ 86,000
Accrued expenses and other current liabilities | $	192,678			$ 253,111
Further Indication for AMR101 | Marketing Approval In Europe
Commitments And Contingencies Disclosure [Line Items]
Potential aggregate stock or cash payment | £					£ 7,500,000
Aggregate stock or cash payment upon potential market approval | £			£ 7,500,000
Further Indication for AMR101 | Potential Marketing Approval 1
Commitments And Contingencies Disclosure [Line Items]
Aggregate stock or cash payment upon potential market approval	6,000	£ 5,000,000.0
Further Indication for AMR101 | Potential Marketing Approval 2
Commitments And Contingencies Disclosure [Line Items]
Aggregate stock or cash payment upon potential market approval	$ 6,000	£ 5,000,000.0