Commitments and Contingencies - Additional Information (Detail) $ in Thousands	Jun. 30, 2022 USD ($)	Jun. 30, 2022 GBP (£)	Dec. 31, 2021 USD ($)
Commitments And Contingencies Disclosure [Line Items]
Future contractual purchase obligations without consideration	$ 81,500
Accrued expenses and other current liabilities	243,064		$ 253,111
Communication costs related to direct-to-consumer activities	600
Further Indication for AMR101 | Marketing Approval In Europe
Commitments And Contingencies Disclosure [Line Items]
Potential aggregate stock or cash payment | £		£ 7,500,000
Accrued expenses and other current liabilities	12,000
Further Indication for AMR101 | Potential Marketing Approval 1
Commitments And Contingencies Disclosure [Line Items]
Aggregate stock or cash payment upon potential market approval	6,100	5,000,000
Further Indication for AMR101 | Potential Marketing Approval 2
Commitments And Contingencies Disclosure [Line Items]
Aggregate stock or cash payment upon potential market approval	$ 6,100	£ 5,000,000