Equity - Incentive Equity Awards - Summary of Equity Awards Activity (Detail) - USD ($)		3 Months Ended
		Mar. 31, 2022	Mar. 31, 2021
Stockholders Equity Note [Line Items]
Common shares issued for stock option exercises		10,602	783,320
Gross and net proceeds from stock option exercises		$ 30,000	$ 2,059,000
Restricted Stock Units (RSUs)
Stockholders Equity Note [Line Items]
Common shares issued in settlement of RSUs and Performance Based RSUs vested		493,381	940,977
Shares retained for settlement of employee tax obligations		161,083	365,463
Performance-Based RSUs
Stockholders Equity Note [Line Items]
Common shares issued in settlement of RSUs and Performance Based RSUs vested	[1]		1,506,428
Shares retained for settlement of employee tax obligations			638,502

[1] Performance-based RSUs vested in connection with the achievement of certain regulatory and sales performance conditions associated with the REDUCE-IT clinical trial and subsequent revenue growth. These performance-based RSUs have fully vested as of August 2021.